Lithium isotopes in marine authigenic or detrital sedimentary archives have been recently used to trace continental weathering over geologic timescales. However, interpretations are predominantly based on the assumption that riverine Li isotopic signals can be propagated through estuaries without modification. Here, we verify this hypothesis by investigating the behaviour of Li isotopes in the Changjiang (Yangtze) River estuary. We observe a conservative mixing of dissolved Li and its isotopes between the Changjiang River water and seawater. The dissolved δ 7 Li yields a non-linear increase with salinity, and a significant increase occurs during the initial water mixing. Through the studied transect, estuarine flocculation and resuspension processes cause the homogenisation of offshore particulate δ 7 Li values, which are close to the average composition of upper continental crust. This study provides clear and direct evidence that the riverine dissolved Li isotopic signal is not modified during estuarine processes in large rivers, but caution should be exercised when using detrital δ 7 Li in marginal seas to investigate past continental weathering.