Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2021

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Murilo Sena Amaral
João V M Malvezzi
Paul L a M Corstjens
Govert J van Dam

Résumé

The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict >200 million people worldwide. By monitoring bloodstream levels of parasitegut-derived antigen, we show that from week 10 onwards an established infection with Schistosoma mansoni is cleared in an exponential manner, eliciting resistance to reinfection. Secondary challenge at week 42 demonstrates that protection is strong in all animals and complete in some. Antibody profiles suggest that antigens mediating protection are the released products of developing schistosomula. In culture they are killed by addition of rhesus plasma, collected from week 8 post-infection onwards, and even more efficiently with postchallenge plasma. Furthermore, cultured schistosomula lose chromatin activating marks at the transcription start site of genes related to worm development and show decreased expression of genes related to lysosomes and lytic vacuoles involved with autophagy. Overall, our results indicate that enhanced antibody responses against the challenge migrating larvae mediate the naturally acquired protective immunity and will inform the route to an effective vaccine.
Fichier principal
Vignette du fichier
Amaral-2021-NatCom-Rhesus.pdf (1.87 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03414204 , version 1 (04-11-2021)

Identifiants

Citer

Murilo Sena Amaral, Daisy Woellner Santos, Adriana S A Pereira, Ana Carolina Tahira, João V M Malvezzi, et al.. Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge. Nature Communications, 2021, 12, ⟨10.1038/s41467-021-26497-0⟩. ⟨hal-03414204⟩
58 Consultations
57 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More