Femtosecond lasers are known to be versatile tools capable to form a variety of hierarchical micro and nanostructures on solid surfaces allowing an efficient control over various surface properties. Among these properties, wettability plays a crucial role in the development of numerous application not only in the industry, but also in the biomedical field. Among other factors, wettability strongly affects the behavior of cells, bacteria and even of viruses. A controllable modulation of the wetting properties affects both osseointegration and mechanotransduction, which are known to be key process in dental and orthopedic implant integration, as well as in the bioengineering in general. Despite a large number of promising experimental results, it is still unclear how to predict and explain the wettability of laser textured surfaces. The classical models, such as the Wenzel and Cassie-Baxter, contain adjustable parameters and provide only rough explanations. The development of more realistic models remain challenging because of the lack of understanding of the effects of both surface and liquid properties on the behavior of a liquid droplet on the surface. In particular, the difficulty arises from the change in surface wettability with time after laser treatment. To better understand this process, we use a continuum-level modeling [1] to study the wetting dynamics of a liquid droplet on laser-textured Ti, Ti alloys, as well as on several other surfaces. The droplet dynamics and the calculated evolutions of the contact angle with time for both structured and non-structured surfaces are examined and are compared to a set of experiments [2]. Our results demonstrate the role of the surface relief and composition. Several explanations are proposed based on the performed modeling, which is shown to be not only suitable for the better understanding of the process involved, but can be also used for the implant relief optimization.