Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Neuroscience Année : 2019

Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response

Résumé

Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na+ gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the mechanisms regulating SERT functions is of priority. Here, we review how genetic and epigenetic regulations, post-translational modifications of SERT, and specific interactions between SERT and a set of diverse partners influence SERT expression, trafficking to and away from the plasma membrane and activity, in connection with the neuronal adaptive cell response to SSRI antidepressants.
Fichier principal
Vignette du fichier
R2019 Baudry et al FrontiersNeurosci.pdf (1.42 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03413480 , version 1 (10-11-2021)

Identifiants

Citer

Anne Baudry, Mathea Pietri, Jean-Marie Launay, Odile Kellermann, B Schneider. Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response. Frontiers in Neuroscience, 2019, 13, ⟨10.3389/fnins.2019.00091⟩. ⟨hal-03413480⟩
16 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More