Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers - Archive ouverte HAL Access content directly
Journal Articles Journal of the American Chemical Society Year : 2021

Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers

Li-Bo Huang
Emilie Moulin
Mihail Barboiu
Nicolas Giuseppone

Abstract

A hydrophobic light-driven rotary motor is functionalized with two 18-crown-6 macrocycles and incorporated into phospholipid bilayers. In the presence of this molecular construct, fluorescence assays and patch clamp experiments show the formation of selective alkali ion channels through the membrane. Further, they reveal a strongly accelerated ion transport mechanism under light irradiation. This increase of the fractional ion transport activity (up to 400%) is attributed to the out-of-equilibrium actuation dynamics of the light-driven rotary motors that helps overcoming the activation energy necessary to achieve translocation of alkali ions between macrocycles along the artificial channels.
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Dates and versions

hal-03410237 , version 1 (09-11-2021)

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Wen-Zhi Wang, Li-Bo Huang, Shao-Ping Zheng, Emilie Moulin, Odile Gavat, et al.. Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers. Journal of the American Chemical Society, 2021, 143 (38), pp.15653-15660. ⟨10.1021/jacs.1c05750⟩. ⟨hal-03410237⟩
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