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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2004

Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes

Résumé

The use of 1-[3-O-(2-cyanoethyl-N,N-diisopropylphosphor amidityl)propyl]ferrocene and 1-[3-O-dimethoxytrityl propyl]-1′-[3′-O-(2-cyanoethyl-N,N-diisopropylphosphoramidityl) propyl] ferrocene as reactive synthons for DNA/RNA synthesizer allows to generate ferrocene-labelled oligonucleotides with remarkable DNA detection properties. A new type of di-functionalized ferrocene is used directly as reactive synthons for DNA/RNA synthesizer to elaborate electronic DNA probes.

Domaines

Chimie

Dates et versions

hal-03409059 , version 1 (29-10-2021)

Identifiants

Citer

Aude-Emmanuelle Navarro, Nicolas Spinelli, Carole Chaix, Corinne Moustrou, Bernard Mandrand, et al.. Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes. Bioorganic and Medicinal Chemistry Letters, 2004, 14 (10), pp.2439-2441. ⟨10.1016/j.bmcl.2004.03.016⟩. ⟨hal-03409059⟩
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