This paper is dedicated to an acoustic scattering problem in a two-dimensional partially open waveguide, in the sense that the left part of the waveguide is closed, that is with a bounded crosssection, while the right part is bounded in the transverse direction by some Perfectly Matched Layers that mimic the situation of an open waveguide, that is with an unbounded cross-section. We prove well-posedness of such scattering problem and exhibit the asymptotic behaviour of the solution in the longitudinal direction with the help of the Kondratiev approach. Having in mind the numerical computation of the solution, we also propose some transparent boundary conditions in such longitudinal direction, based on Dirichlet-to-Neumann operators. After proving that such artificial conditions actually enable us to approximate the exact solution, some numerical experiments illustrate the quality of such approximation.