Production of titania nanoparticles from TiCl 4 precursor in 1-D laminar flames is investigated through numerical simulations. First, the impact of mass and enthalpy conservation in the modeling of nanoparticles production in reactive flows is investigated when considering high concentrations of particles precursor, classically characterizing the industrial applications. Then, a new model is developed accounting for a detailed description of TiCl 4 oxidation and a new hydrolysis pathway. Its performance is evaluated in premixed and non-premixed laminar configurations by comparison with state-of-the-art descriptions. Finally, TiO 2 production is characterized in both premixed and diffusion flames in terms of particle size Distributions (PSDs), in order to provide first indications on the optimization of TiO 2 flame synthesis.