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              <p>Studies of the room temperature synthesis of Metal-Organic Frameworks (MOFs) are still scarce and mainly focused on divalent metals based MOFs. The development of room temperature synthesis of more chemically robust MOFs is still challenging and therefore lacks of exploration. Here, we review the development of ambient conditions synthesis of MOFs, from the properties of the sole MOF to their related composites. Low temperature green synthesis can not only meet the standards of sustainable chemistry, but also help to achieve a series of property enhancements, including their applications in catalysis, biomedicine, and sensing. Finally, perspectives associated to the synthesis strategies and applications of room temperature methods are discussed.</p>
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