NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2021

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

Benjamin Compans
Come Camus
Emmanouela Kallergi
  • Fonction : Auteur
Silvia Sposini
  • Fonction : Auteur
Magalie Martineau
  • Fonction : Auteur
Corey Butler
Adel Kechkar
  • Fonction : Auteur
Remco V Klaassen
  • Fonction : Auteur
Natacha Retailleau
  • Fonction : Auteur
Terrence J Sejnowski
  • Fonction : Auteur
August B Smit
Jean-Baptiste Sibarita
Thomas M Bartol
  • Fonction : Auteur
David Perrais
Vassiliki Nikoletopoulou
  • Fonction : Auteur
Daniel Choquet

Résumé

Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD encompasses various induction pathways, including activation of NMDA, mGlu or P2X receptors. However, the associated specific molecular mechanisms and effects on synaptic physiology are still unclear. We here compare how NMDAR-or P2XR-dependent LTD affect synaptic nanoscale organization and function in rodents. While both LTDs are associated with a loss and reorganization of synaptic AMPARs, only NMDAR-dependent LTD induction triggers a profound reorganization of PSD-95. This modification, which requires the autophagy machinery to remove the T19-phosphorylated form of PSD-95 from synapses, leads to an increase in AMPAR surface mobility. We demonstrate that these post-synaptic changes that occur specifically during NMDAR-dependent LTD result in an increased short-term plasticity improving neuronal responsiveness of depressed synapses. Our results establish that P2XRand NMDAR-mediated LTD are associated to functionally distinct forms of LTD.

Domaines

Neurosciences
Fichier principal
Vignette du fichier
2021 Compans et al. nat. com..pdf (6.8 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03382542 , version 1 (18-10-2021)

Identifiants

Citer

Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, et al.. NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. Nature Communications, 2021, 12, ⟨10.1038/s41467-021-23133-9⟩. ⟨hal-03382542⟩

Collections

CNRS ANR FRM
38 Consultations
21 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More