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Article Dans Une Revue Organic Letters Année : 2021

Synthesis of α-Amino Acid N-Carboxyanhydrides

Résumé

A simple phosgene- and halogen-free method for synthesizing α-amino acid N-carboxyanhydrides (NCAs) is described. The reaction between Boc-protected α-amino acids and T3P reagent gave the corresponding NCA derivatives in good yield and purity with no detectable epimerization. The process is safe, is easy-to-operate, and does not require any specific installation. It generates nontoxic, easy to remove byproducts. It can apply to the preparation of NCAs for the on-demand on-site production of either little or large quantities.
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Dates et versions

hal-03402385 , version 1 (25-10-2021)

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Guillaume Laconde, Muriel Amblard, Jean Martinez. Synthesis of α-Amino Acid N-Carboxyanhydrides. Organic Letters, 2021, 23 (16), pp.6412-6416. ⟨10.1021/acs.orglett.1c02224⟩. ⟨hal-03402385⟩
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