<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03394859</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T16:47:51+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Cold atmospheric single plasma jet for RONS delivery on large biological surfaces</title>
            <author role="aut">
              <persName>
                <forename type="first">Azadeh</forename>
                <surname>Valinataj Omran</surname>
              </persName>
              <email type="md5">d3c92ce1554242816117c8d189715652</email>
              <email type="domain">hotmail.com</email>
              <idno type="idhal" notation="numeric">1019965</idno>
              <idno type="halauthorid" notation="string">1396831-1019965</idno>
              <affiliation ref="#struct-199965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Giovanni</forename>
                <surname>Busco</surname>
              </persName>
              <email type="md5">bfab8b936a846229905879b21312c8ce</email>
              <email type="domain">hotmail.com</email>
              <idno type="idhal" notation="string">giovanni-busco</idno>
              <idno type="idhal" notation="numeric">18189</idno>
              <idno type="halauthorid" notation="string">30607-18189</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6859-9468</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-2711-2018</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-2711-2018</idno>
              <affiliation ref="#struct-451"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loick</forename>
                <surname>Ridou</surname>
              </persName>
              <idno type="halauthorid">909832-0</idno>
              <affiliation ref="#struct-451"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Dozias</surname>
              </persName>
              <idno type="halauthorid">170775-0</idno>
              <affiliation ref="#struct-199965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Grillon</surname>
              </persName>
              <email type="md5">71c3a105961c692b1752fda13b9cb11b</email>
              <email type="domain">cnrs-orleans.fr</email>
              <idno type="idhal" notation="string">catherine-grillon</idno>
              <idno type="idhal" notation="numeric">174547</idno>
              <idno type="halauthorid" notation="string">8916-174547</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5019-7831</idno>
              <idno type="IDREF">https://www.idref.fr/110411218</idno>
              <affiliation ref="#struct-451"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean Michel</forename>
                <surname>Pouvesle</surname>
              </persName>
              <email type="md5">1e72c698ce08db4984fe703dddfe9162</email>
              <email type="domain">univ-orleans.fr</email>
              <idno type="idhal" notation="string">jean-michel-pouvesle</idno>
              <idno type="idhal" notation="numeric">170616</idno>
              <idno type="halauthorid" notation="string">250687-170616</idno>
              <idno type="IDREF">https://www.idref.fr/031516483</idno>
              <affiliation ref="#struct-199965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Robert</surname>
              </persName>
              <email type="md5">76b37b6bef493e9d7fb2df07a380e4f3</email>
              <email type="domain">univ-orleans.fr</email>
              <idno type="idhal" notation="string">sc-robert</idno>
              <idno type="idhal" notation="numeric">739408</idno>
              <idno type="halauthorid" notation="string">9832-739408</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-7992-2019</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7894-7080</idno>
              <idno type="IDREF">https://www.idref.fr/180388436</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-7992-2019</idno>
              <affiliation ref="#struct-199965"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Catherine</forename>
                <surname>GRILLON</surname>
              </persName>
              <email type="md5">71c3a105961c692b1752fda13b9cb11b</email>
              <email type="domain">cnrs-orleans.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-10-22 11:28:25</date>
              <date type="whenModified">2025-10-17 16:28:02</date>
              <date type="whenReleased">2021-10-22 11:28:25</date>
              <date type="whenProduced">2020-12-09</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="567591">
                <persName>
                  <forename>Catherine</forename>
                  <surname>GRILLON</surname>
                </persName>
                <email type="md5">71c3a105961c692b1752fda13b9cb11b</email>
                <email type="domain">cnrs-orleans.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03394859</idno>
            <idno type="halUri">https://hal.science/hal-03394859</idno>
            <idno type="halBibtex">valinatajomran:hal-03394859</idno>
            <idno type="halRefHtml">&lt;i&gt;30th annual meeting of MRS-J (2020), International Symposium K Plasma Lifescience&lt;/i&gt;, Dec 2020, Virtual, France</idno>
            <idno type="halRef">30th annual meeting of MRS-J (2020), International Symposium K Plasma Lifescience, Dec 2020, Virtual, France</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TOURS">Université François Rabelais</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ORLEANS">Université d'Orléans</idno>
            <idno type="stamp" n="CBM">Centre de biophysique moléculaire</idno>
            <idno type="stamp" n="GREMI" corresp="UNIV-ORLEANS">Publications du GREMI</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="BCT" corresp="CBM">Biologie Cellulaire, Cibles moléculaires et Thérapies innovantes</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="BIOBRAT" corresp="CBM">Biologie et Biophysique des récepteurs, applications translationnelles</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Cold atmospheric single plasma jet for RONS delivery on large biological surfaces</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Azadeh</forename>
                    <surname>Valinataj Omran</surname>
                  </persName>
                  <email type="md5">d3c92ce1554242816117c8d189715652</email>
                  <email type="domain">hotmail.com</email>
                  <idno type="idhal" notation="numeric">1019965</idno>
                  <idno type="halauthorid" notation="string">1396831-1019965</idno>
                  <affiliation ref="#struct-199965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Giovanni</forename>
                    <surname>Busco</surname>
                  </persName>
                  <email type="md5">bfab8b936a846229905879b21312c8ce</email>
                  <email type="domain">hotmail.com</email>
                  <idno type="idhal" notation="string">giovanni-busco</idno>
                  <idno type="idhal" notation="numeric">18189</idno>
                  <idno type="halauthorid" notation="string">30607-18189</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6859-9468</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-2711-2018</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-2711-2018</idno>
                  <affiliation ref="#struct-451"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loick</forename>
                    <surname>Ridou</surname>
                  </persName>
                  <idno type="halauthorid">909832-0</idno>
                  <affiliation ref="#struct-451"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Dozias</surname>
                  </persName>
                  <idno type="halauthorid">170775-0</idno>
                  <affiliation ref="#struct-199965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Grillon</surname>
                  </persName>
                  <email type="md5">71c3a105961c692b1752fda13b9cb11b</email>
                  <email type="domain">cnrs-orleans.fr</email>
                  <idno type="idhal" notation="string">catherine-grillon</idno>
                  <idno type="idhal" notation="numeric">174547</idno>
                  <idno type="halauthorid" notation="string">8916-174547</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5019-7831</idno>
                  <idno type="IDREF">https://www.idref.fr/110411218</idno>
                  <affiliation ref="#struct-451"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean Michel</forename>
                    <surname>Pouvesle</surname>
                  </persName>
                  <email type="md5">1e72c698ce08db4984fe703dddfe9162</email>
                  <email type="domain">univ-orleans.fr</email>
                  <idno type="idhal" notation="string">jean-michel-pouvesle</idno>
                  <idno type="idhal" notation="numeric">170616</idno>
                  <idno type="halauthorid" notation="string">250687-170616</idno>
                  <idno type="IDREF">https://www.idref.fr/031516483</idno>
                  <affiliation ref="#struct-199965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Robert</surname>
                  </persName>
                  <email type="md5">76b37b6bef493e9d7fb2df07a380e4f3</email>
                  <email type="domain">univ-orleans.fr</email>
                  <idno type="idhal" notation="string">sc-robert</idno>
                  <idno type="idhal" notation="numeric">739408</idno>
                  <idno type="halauthorid" notation="string">9832-739408</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-7992-2019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7894-7080</idno>
                  <idno type="IDREF">https://www.idref.fr/180388436</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-7992-2019</idno>
                  <affiliation ref="#struct-199965"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">BIOBRAT</idno>
                <meeting>
                  <title>30th annual meeting of MRS-J (2020), International Symposium K Plasma Lifescience</title>
                  <date type="start">2020-12-09</date>
                  <date type="end">2020-12-11</date>
                  <settlement>Virtual</settlement>
                  <country key="FR">France</country>
                </meeting>
                <imprint/>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep.derm">Life Sciences [q-bio]/Human health and pathology/Dermatology</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdv.bc.bc">Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]</classCode>
              <classCode scheme="halDomain" n="sdv.bc.ic">Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Several attempts have been made to deliver reactive oxygen and nitrogen species (RONS) produced by non-thermal plasma onto large surfaces in a controllable way compatible with skin treatments. In this paper, the effect of pulse frequency, in the range 0.5–20 kHz, on the discharge behavior was studied on skin tissue models to evaluate potential treatment changes. This has been done through electrical characterization, visualization of the helium flow (by Schlieren technique), produced plasma jet modifications (ICCD imaging) and RONS measurements. The results show that, in addition to its well known important role in the production of the chemical species, the applied discharge frequency plays a very significant role in the size of the treated surface. An enhancement of NO*, OH* and O* production in the gas phase at the higher frequency is reported and assigned to the stronger mixing of the helium flow with ambient air. The efficacy of plasma jet on transporting RONS on/into agarose gel and pig skin has been evaluated. The distribution of the reactive species on the target, or passing through, is strongly dependent on the discharge frequency and consequently induces pH variations. The present study supports a new way for enlarging the treated surface by using a simple jet at high frequency in the 20 kHz range, leading, with appropriate gas flow and distance to target, to conditions of RONS production that are compatible with potential uses for biomedical or cosmetic applications.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-199965" status="VALID">
          <idno type="IdRef">195138678</idno>
          <idno type="ISNI">0000000085172151</idno>
          <idno type="RNSR">201220227N</idno>
          <idno type="ROR">https://ror.org/042ds2135</idno>
          <orgName>Groupe de recherches sur l'énergétique des milieux ionisés</orgName>
          <orgName type="acronym">GREMI</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>14 Rue d'Issoudun - BP 6744 45067 ORLEANS CEDEX 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-orleans.fr/gremi/</ref>
          </desc>
          <listRelation>
            <relation name="UMR 7344" active="#struct-300297" type="direct"/>
            <relation name="UMR7344" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-451" status="VALID">
          <idno type="IdRef">170121070</idno>
          <idno type="ISNI">0000000406148532</idno>
          <idno type="RNSR">196717612S</idno>
          <idno type="ROR">https://ror.org/02dpqcy73</idno>
          <orgName>Centre de biophysique moléculaire</orgName>
          <orgName type="acronym">CBM - UPR 4301</orgName>
          <date type="start">1967-01-01</date>
          <desc>
            <address>
              <addrLine>Rue Charles Sadron 45071 ORLEANS CEDEX 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cbm.cnrs-orleans.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UPR4301" active="#struct-300297" type="direct"/>
            <relation active="#struct-300298" type="direct"/>
            <relation name="UPR4301" active="#struct-303623" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UPR4301" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300297" status="VALID">
          <idno type="IdRef">026402971</idno>
          <idno type="ISNI">0000 0001 2158 1666</idno>
          <idno type="ROR">https://ror.org/014zrew76</idno>
          <orgName>Université d'Orléans</orgName>
          <orgName type="acronym">UO</orgName>
          <desc>
            <address>
              <addrLine>Château de la Source - Avenue du Parc Floral - BP 6749 - 45067 Orléans cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-orleans.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300298" status="VALID">
          <idno type="IdRef">026404478</idno>
          <idno type="ISNI">0000000121608742</idno>
          <idno type="ROR">https://ror.org/02wwzvj46</idno>
          <orgName>Université de Tours</orgName>
          <orgName type="acronym">UT</orgName>
          <date type="start">1970-12-17</date>
          <desc>
            <address>
              <addrLine>60 rue du Plat d'Étain, 37020 Tours cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tours.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>