TotemBioNet Enrichment Methodology: Application to the Qualitative Regulatory Network of the Cell Metabolism
Résumé
When designing a biological regulatory network, new information or wet experiments can require adding variables or interactions, inside a previously validated model. They can result in complete reconsiderations of established behaviours. Fortunately, formal methods allow for fully automated verification of properties, and TotemBioNet is an efficient software integrating a collection of formal approaches for regulatory networks. It allowed us to develop a multidisciplinary methodology for designing large dynamical models in an incremental way, including non regression proofs (preservation of important biological properties).
Origine | Fichiers produits par l'(les) auteur(s) |
---|