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Pré-Publication, Document De Travail Année : 2021

Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task

Malou Dongelmans
  • Fonction : Auteur
Romain Durand-de Cuttoli
Claire Nguyen
Maxime Come
  • Fonction : Auteur
Etienne Duranté
Damien Lemoine
  • Fonction : Auteur
  • PersonId : 758080
  • IdRef : 14520023X
Raphael Britto
  • Fonction : Auteur
Tarek Ahmed Yahia
  • Fonction : Auteur
Sarah Mondoloni
Steve Didienne
Elise Bousseyrol
Bernadette Hannesse
  • Fonction : Auteur
Lauren Reynolds
Nicolas Torquet
Deniz Dalkara
Fabio Marti
Alexandre Mourot
  • Fonction : Auteur
  • PersonId : 1015109
  • IdHAL : almourot
Philippe Faure

Résumé

Summary Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related and unrelated to drug seeking and consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated the impact of chronic nicotine on the trade-off between exploitation and exploration, and the role of ventral tegmental area (VTA) dopamine (DA) neuron activity in decision-making unrelated to nicotine-seeking. Model-based and archetypal analysis revealed a substantial inter-individual variability in decision-making strategies, with mice passively exposed to chronic nicotine visiting more frequently options associated with higher reward probability and therefore shifting toward a more exploitative profile compared to non-exposed animals. We then mimicked the effect of chronic nicotine on the tonic activity of VTA DA neurons using optogenetics, and found that photo-stimulated mice had a behavioral phenotype very close to that of mice exposed to nicotine, suggesting that the dopaminergic control of the exploration/exploitation balance is altered under nicotine exposure. Our results thus reveal a key role of tonic midbrain DA in the exploration/exploitation trade-off and highlight a potential mechanism by which nicotine affects decision-making.

Dates et versions

hal-03379664 , version 1 (15-10-2021)

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Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne Duranté, et al.. Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task. 2021. ⟨hal-03379664⟩

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