COVID-19 and metabolic disease: mechanisms and clinical management
Charlotte Steenblock
(1)
,
Peter Schwarz
(1, 2)
,
Barbara Ludwig
(1, 3, 2, 4)
,
Andreas Linkermann
(1)
,
Paul Zimmet
(5)
,
Konstantin Kulebyakin
(6)
,
Vsevolod Tkachuk
(6)
,
Alexander Markov
(7)
,
Hendrik Lehnert
(8)
,
Martin Hrabě de Angelis
(9, 10, 11)
,
Hannes Rietzsch
(1)
,
Roman Rodionov
(1)
,
Kamlesh Khunti
(12)
,
David Hopkins
(13)
,
Andreas Birkenfeld
(1, 2, 13, 14, 15, 10)
,
Bernhard Boehm
(16, 17)
,
Richard Holt
(18)
,
Jay Skyler
(19)
,
J Hans Devries
(20, 21)
,
Eric Renard
(22, 23)
,
Robert Eckel
(24)
,
K George M M Alberti
(25)
,
Bruno Geloneze
(26)
,
Juliana Chan
(27)
,
Jean Claude Mbanya
(28)
,
Henry Onyegbutulem
(29)
,
Ambady Ramachandran
(30)
,
Abdul Basit
(31)
,
Mohamed Hassanein
(32)
,
Gavin Bewick
(13)
,
Giatgen Spinas
(3)
,
Felix Beuschlein
(3)
,
Rüdiger Landgraf
(33)
,
Francesco Rubino
(13, 34)
,
Geltrude Mingrone
(13, 35, 36)
,
Stefan Bornstein
(1, 2, 3, 13)
1
TU Dresden -
Technische Universität Dresden = Dresden University of Technology
2 University Hospital Carl Gustav Carus [Dresden, Germany]
3 University hospital of Zurich [Zurich]
4 Paul Langerhans Institute of the Helmholtz Center Munich
5 Monash University [Melbourne]
6 MSU - Lomonosov Moscow State University
7 SPbU - St Petersburg State University
8 University of Salzburg
9 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
10 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
11 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
12 University of Leicester
13 King‘s College London
14 Universitätsklinikum Tübingen - University Hospital of Tübingen
15 Eberhard Karls Universität Tübingen = University of Tübingen
16 Tan Tock Seng Hospital
17 Nanyang Technological University [Singapour]
18 University of Southampton
19 UMMSM - University of Miami Leonard M. Miller School of Medicine
20 Amsterdam UMC - Amsterdam University Medical Center
21 Profil Institute for Metabolic Research GmbH
22 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
23 IGF - Institut de Génomique Fonctionnelle
24 University of Colorado Anschutz [Aurora]
25 Imperial College London
26 UNICAMP - Universidade Estadual de Campinas = University of Campinas
27 CUHK - The Chinese University of Hong Kong [Hong Kong]
28 University of Yaoundé [Cameroun]
29 UNN - University of Nigeria
30 Chennai, India
31 University of Karachi
32 Dubai Hospital
33 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
34 Kings College Hopsital
35 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
36 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
2 University Hospital Carl Gustav Carus [Dresden, Germany]
3 University hospital of Zurich [Zurich]
4 Paul Langerhans Institute of the Helmholtz Center Munich
5 Monash University [Melbourne]
6 MSU - Lomonosov Moscow State University
7 SPbU - St Petersburg State University
8 University of Salzburg
9 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
10 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
11 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
12 University of Leicester
13 King‘s College London
14 Universitätsklinikum Tübingen - University Hospital of Tübingen
15 Eberhard Karls Universität Tübingen = University of Tübingen
16 Tan Tock Seng Hospital
17 Nanyang Technological University [Singapour]
18 University of Southampton
19 UMMSM - University of Miami Leonard M. Miller School of Medicine
20 Amsterdam UMC - Amsterdam University Medical Center
21 Profil Institute for Metabolic Research GmbH
22 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
23 IGF - Institut de Génomique Fonctionnelle
24 University of Colorado Anschutz [Aurora]
25 Imperial College London
26 UNICAMP - Universidade Estadual de Campinas = University of Campinas
27 CUHK - The Chinese University of Hong Kong [Hong Kong]
28 University of Yaoundé [Cameroun]
29 UNN - University of Nigeria
30 Chennai, India
31 University of Karachi
32 Dubai Hospital
33 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
34 Kings College Hopsital
35 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
36 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
Martin Hrabě de Angelis
- Fonction : Auteur
- PersonId : 758367
- ORCID : 0000-0002-7898-2353
- IdRef : 115604332
Andreas Birkenfeld
- Fonction : Auteur
Bernhard Boehm
- Fonction : Auteur
Jay Skyler
- Fonction : Auteur
- PersonId : 806749
- ORCID : 0000-0003-1136-8110
Eric Renard
- Fonction : Auteur
- PersonId : 759202
- ORCID : 0000-0002-3407-7263
- IdRef : 031106218
Felix Beuschlein
- Fonction : Auteur
- PersonId : 758956
- ORCID : 0000-0001-7826-3984
Résumé
Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.