Article Dans Une Revue Trends in Immunology Année : 2020

Origins of the RAG Transposome and the MHC

Résumé

How innate immunity gave rise to adaptive immunity in vertebrates remains unknown. We propose an evolutionary scenario beginning with pathogen-associated molecular pattern(s) (PAMPs) being presented by molecule(s) on one cell to specific receptor(s) on other cells, much like MHC molecules and T cell receptors (TCRs). In this model, mutations in MHC-like molecule(s) that bound new PAMP(s) would not be recognized by original TCR-like molecule(s), and new MHC-like gene(s) would be lost by neutral drift. Integrating recombination activating gene (RAG) transposon(s) in a TCR-like gene would result in greater recognition diversity, with new MHC-like variants recognized and selected, along with a new RAG/TCR-like system. MHC genes would be selected to present many peptides, through multigene families, allelic polymorphism, and peptide-binding promiscuity.

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hal-03371051 , version 1 (08-10-2021)

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Louis Tsakou-Ngouafo, Julien Paganini, Jim Kaufman, Pierre Pontarotti. Origins of the RAG Transposome and the MHC. Trends in Immunology, 2020, 41 (7), pp.561-571. ⟨10.1016/j.it.2020.05.002⟩. ⟨hal-03371051⟩
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