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Article Dans Une Revue Brain - A Journal of Neurology Année : 2021

Reply: Lesion network mapping predicts post-stroke behavioural deficits and improves localization

Victor Nozais
Stephanie Forkel
Chris Foulon
Laurent Petit
Alessandro Salvalaggio
Michele de Filippo de Grazia
  • Fonction : Auteur
Lorenzo Pini
Marco Zorzi
Maurizio Corbetta
  • Fonction : Auteur

Résumé

Abstract In recent years, the field of functional neuroimaging has moved away from a pure localisationist approach of isolated functional brain regions to a more integrated view of these regions within functional networks. However, the methods used to investigate functional networks rely on local signals in grey matter and are limited in identifying anatomical circuitries supporting the interaction between brain regions. Mapping the brain circuits mediating the functional signal between brain regions would propel our understanding of the brain’s functional signatures and dysfunctions. We developed a method to unravel the relationship between brain circuits and functions: The Functionnectome. The Functionnectome combines the functional signal from fMRI with white matter circuits’ anatomy to unlock and chart the first maps of functional white matter. To showcase this method’s versatility, we provide the first functional white matter maps revealing the joint contribution of connected areas to motor, working memory, and language functions. The Functionnectome comes with an open-source companion software and opens new avenues into studying functional networks by applying the method to already existing datasets and beyond task fMRI.

Dates et versions

hal-03370233 , version 1 (07-10-2021)

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Citer

Michel Thiebaut de Schotten, Victor Nozais, Stephanie Forkel, Chris Foulon, Laurent Petit, et al.. Reply: Lesion network mapping predicts post-stroke behavioural deficits and improves localization. Brain - A Journal of Neurology , 2021, 144 (4), pp.e36-e36. ⟨10.1093/brain/awab004⟩. ⟨hal-03370233⟩

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