With the advent of more and more sophisticated driving assistance systems on the market, the use of driving simulators to test them has become nearly compulsory. The number of research papers involving simulator studies that were published in recent years testifies such importance. This popularity is also demonstrated through large investments performed by major car manufacturers to acquire state-of-the-art high performance simulators. The current Special Issue gathers 9 high-quality studies. The contributions were chosen among the best papers of the 17th Driving Simulation & Virtual Reality Conference, a now well-established conference in the driving simulation community and published as two-page abstracts in the proceedings of the conference. These contributions cover a wide range of aspects related to the use of driving simulators.