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Article Dans Une Revue Scientific Reports Année : 2021

Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal
Karen Brengel-Pesce
Alexandre Gaymard
Grégory Queromes
Nicolas Guibert
Emilie Frobert
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Maude Bouscambert
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Mary-Anne Trabaud
Florence Allantaz-Frager
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Guy Oriol
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Valérie Cheynet
Constance D'aubarede
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Marlyse Buisson
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Julien Lupo
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Bruno Pozzetto
Pascal Poignard
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Bruno Lina
Jean-Baptiste Fassier
Florence Morfin
Sophie Trouillet-Assant

Résumé

A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p?=?0.07). The proportion of HCWs with a viral load?>?5.0 log10cp/mL (Ct value??37). More than 90% of cultivable virus had a viral load?>?4.5 log10cp/mL (Ct?

Dates et versions

hal-03366572 , version 1 (05-10-2021)

Identifiants

Citer

Antonin Bal, Karen Brengel-Pesce, Alexandre Gaymard, Grégory Queromes, Nicolas Guibert, et al.. Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study. Scientific Reports, 2021, 11 (1), 10 p. ⟨10.1038/s41598-021-93828-y⟩. ⟨hal-03366572⟩
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