The Multifaceted Role of Protein Phosphatase 1 in Plasmodium - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Trends in Parasitology Année : 2021

The Multifaceted Role of Protein Phosphatase 1 in Plasmodium

Résumé

Protein phosphatase type 1 (PP1) forms a wide range of Ser/Thr-specific phosphatase holoenzymes which contain one catalytic subunit (PP1c), present in all eukaryotic cells, associated with variable subunits known as regulatory proteins. It has recently been shown that regulators take a leading role in the organization and the control of PP1 functions. Many studies have addressed the role of these regulators in diverse organisms, including humans, and investigated their link to diseases. In this review we summarize recent advances on the role of PP1c in Plasmodium, its interactome and regulators. As a proof of concept, peptides interfering with the regulator binding capacity of PP1c were shown to inhibit the growth of P. falciparum, suggesting their potential as drug precursors.
Fichier principal
Vignette du fichier
pdf-Ms-final.pdf (1.05 Mo) Télécharger le fichier
Figure 1.pdf (825.63 Ko) Télécharger le fichier
Figure 2.pdf (259 Ko) Télécharger le fichier
Figure 3.pdf (225.78 Ko) Télécharger le fichier
Glossary 03092020.pdf (299.58 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03365541 , version 1 (05-10-2021)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Jamal Khalife, Aline Fréville, Bénédicte Gnangnon, Christine Pierrot. The Multifaceted Role of Protein Phosphatase 1 in Plasmodium. Trends in Parasitology, 2021, 37 (2), pp.154-164. ⟨10.1016/j.pt.2020.09.003⟩. ⟨hal-03365541⟩
123 Consultations
162 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More