<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03364400</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-05T16:18:14+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The SOUL family of heme-binding proteins: Structure and function 15 years later</title>
            <author role="crp">
              <persName>
                <forename type="first">Brian J.</forename>
                <surname>Goodfellow</surname>
              </persName>
              <email type="md5">436ae17bb5137c02f2066f180665c2ba</email>
              <email type="domain">ua.pt</email>
              <idno type="idhal" notation="numeric">1112177</idno>
              <idno type="halauthorid" notation="string">2298553-1112177</idno>
              <affiliation ref="#struct-1077985"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Filipe</forename>
                <surname>Freire</surname>
              </persName>
              <idno type="halauthorid">2298554-0</idno>
              <affiliation ref="#struct-345590"/>
              <affiliation ref="#struct-140112"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ana Luisa</forename>
                <surname>Carvalho</surname>
              </persName>
              <idno type="halauthorid">1351773-0</idno>
              <affiliation ref="#struct-486782"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Susana S.</forename>
                <surname>Aveiro</surname>
              </persName>
              <idno type="halauthorid">2298555-0</idno>
              <affiliation ref="#struct-1077986"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Peggy</forename>
                <surname>Charbonnier</surname>
              </persName>
              <idno type="halauthorid">391906-0</idno>
              <affiliation ref="#struct-1061075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean Marc</forename>
                <surname>Moulis</surname>
              </persName>
              <email type="md5">a6bad16b3f23a83bdc61aad531d7cfdb</email>
              <email type="domain">cea.fr</email>
              <idno type="idhal" notation="numeric">1373779</idno>
              <idno type="halauthorid" notation="string">1462783-1373779</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5615-9852</idno>
              <idno type="IDREF">https://www.idref.fr/060586605</idno>
              <affiliation ref="#struct-1043285"/>
              <affiliation ref="#struct-1043297"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Leonildo</forename>
                <surname>Delgado</surname>
              </persName>
              <idno type="halauthorid">2298556-0</idno>
              <affiliation ref="#struct-1077987"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gloria C.</forename>
                <surname>Ferreira</surname>
              </persName>
              <idno type="halauthorid">2298557-0</idno>
              <affiliation ref="#struct-1042959"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">João E.</forename>
                <surname>Rodrigues</surname>
              </persName>
              <idno type="halauthorid">2298558-0</idno>
              <affiliation ref="#struct-188849"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Poussin-Courmontagne</surname>
              </persName>
              <email type="md5">469bf4c3b0a34d7d440725b020d21c82</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="string">pierre-poussin-courmontagne</idno>
              <idno type="idhal" notation="numeric">1145937</idno>
              <idno type="halauthorid" notation="string">240743-1145937</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4813-6882</idno>
              <affiliation ref="#struct-576664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Birck</surname>
              </persName>
              <email type="md5">1197c4755c218cc7bdf3fa7e45bae23b</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="string">catherine-birck</idno>
              <idno type="idhal" notation="numeric">1145938</idno>
              <idno type="halauthorid" notation="string">222118-1145938</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1624-255X</idno>
              <affiliation ref="#struct-576664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alastair</forename>
                <forename type="middle">G</forename>
                <surname>Mcewen</surname>
              </persName>
              <email type="md5">042f36e29224c08e0835a214b1cf37ce</email>
              <email type="domain">igbmc.fr</email>
              <idno type="idhal" notation="string">alastair-mcewen</idno>
              <idno type="idhal" notation="numeric">1080593</idno>
              <idno type="halauthorid" notation="string">1586074-1080593</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4484-3512</idno>
              <idno type="IDREF">https://www.idref.fr/093584318</idno>
              <affiliation ref="#struct-576664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anjos L.</forename>
                <surname>Macedo</surname>
              </persName>
              <idno type="halauthorid">2298559-0</idno>
              <affiliation ref="#struct-486782"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Nathalie</forename>
                <surname>GON</surname>
              </persName>
              <email type="md5">56526fba23ce83dadd7c14312fee2382</email>
              <email type="domain">cea.fr</email>
            </editor>
            <funder ref="#projanr-37796"/>
            <funder ref="#projanr-55006"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-10-04 16:12:43</date>
              <date type="whenModified">2026-02-07 05:21:51</date>
              <date type="whenReleased">2021-10-04 16:12:43</date>
              <date type="whenProduced">2021-12-01</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="301899">
                <persName>
                  <forename>Nathalie</forename>
                  <surname>GON</surname>
                </persName>
                <email type="md5">56526fba23ce83dadd7c14312fee2382</email>
                <email type="domain">cea.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03364400</idno>
            <idno type="halUri">https://hal.science/hal-03364400</idno>
            <idno type="halBibtex">goodfellow:hal-03364400</idno>
            <idno type="halRefHtml">&lt;i&gt;Coordination Chemistry Reviews&lt;/i&gt;, 2021, 448, pp.214189. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ccr.2021.214189"&gt;&amp;#x27E8;10.1016/j.ccr.2021.214189&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Coordination Chemistry Reviews, 2021, 448, pp.214189. &amp;#x27E8;10.1016/j.ccr.2021.214189&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGBMC" corresp="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="IRTSV-CBM" corresp="IRTSV">BIG - Chimie et Biologie des Métaux (CBM)</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="BIG" corresp="CEA">Institut de Biosciences et Biotechnologies de Grenoble</idno>
            <idno type="stamp" n="LBFA">Laboratoire de Bioénergétique Fondamentale et Appliquée</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
            <idno type="stamp" n="UNISTRA-ITI">Publications ITI Strasbourg</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The SOUL family of heme-binding proteins: Structure and function 15 years later</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Brian J.</forename>
                    <surname>Goodfellow</surname>
                  </persName>
                  <email type="md5">436ae17bb5137c02f2066f180665c2ba</email>
                  <email type="domain">ua.pt</email>
                  <idno type="idhal" notation="numeric">1112177</idno>
                  <idno type="halauthorid" notation="string">2298553-1112177</idno>
                  <affiliation ref="#struct-1077985"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Filipe</forename>
                    <surname>Freire</surname>
                  </persName>
                  <idno type="halauthorid">2298554-0</idno>
                  <affiliation ref="#struct-345590"/>
                  <affiliation ref="#struct-140112"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ana Luisa</forename>
                    <surname>Carvalho</surname>
                  </persName>
                  <idno type="halauthorid">1351773-0</idno>
                  <affiliation ref="#struct-486782"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Susana S.</forename>
                    <surname>Aveiro</surname>
                  </persName>
                  <idno type="halauthorid">2298555-0</idno>
                  <affiliation ref="#struct-1077986"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peggy</forename>
                    <surname>Charbonnier</surname>
                  </persName>
                  <idno type="halauthorid">391906-0</idno>
                  <affiliation ref="#struct-1061075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean Marc</forename>
                    <surname>Moulis</surname>
                  </persName>
                  <email type="md5">a6bad16b3f23a83bdc61aad531d7cfdb</email>
                  <email type="domain">cea.fr</email>
                  <idno type="idhal" notation="numeric">1373779</idno>
                  <idno type="halauthorid" notation="string">1462783-1373779</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5615-9852</idno>
                  <idno type="IDREF">https://www.idref.fr/060586605</idno>
                  <affiliation ref="#struct-1043285"/>
                  <affiliation ref="#struct-1043297"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Leonildo</forename>
                    <surname>Delgado</surname>
                  </persName>
                  <idno type="halauthorid">2298556-0</idno>
                  <affiliation ref="#struct-1077987"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gloria C.</forename>
                    <surname>Ferreira</surname>
                  </persName>
                  <idno type="halauthorid">2298557-0</idno>
                  <affiliation ref="#struct-1042959"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">João E.</forename>
                    <surname>Rodrigues</surname>
                  </persName>
                  <idno type="halauthorid">2298558-0</idno>
                  <affiliation ref="#struct-188849"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Poussin-Courmontagne</surname>
                  </persName>
                  <email type="md5">469bf4c3b0a34d7d440725b020d21c82</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="string">pierre-poussin-courmontagne</idno>
                  <idno type="idhal" notation="numeric">1145937</idno>
                  <idno type="halauthorid" notation="string">240743-1145937</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4813-6882</idno>
                  <affiliation ref="#struct-576664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Birck</surname>
                  </persName>
                  <email type="md5">1197c4755c218cc7bdf3fa7e45bae23b</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="string">catherine-birck</idno>
                  <idno type="idhal" notation="numeric">1145938</idno>
                  <idno type="halauthorid" notation="string">222118-1145938</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1624-255X</idno>
                  <affiliation ref="#struct-576664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alastair</forename>
                    <forename type="middle">G</forename>
                    <surname>Mcewen</surname>
                  </persName>
                  <email type="md5">042f36e29224c08e0835a214b1cf37ce</email>
                  <email type="domain">igbmc.fr</email>
                  <idno type="idhal" notation="string">alastair-mcewen</idno>
                  <idno type="idhal" notation="numeric">1080593</idno>
                  <idno type="halauthorid" notation="string">1586074-1080593</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4484-3512</idno>
                  <idno type="IDREF">https://www.idref.fr/093584318</idno>
                  <affiliation ref="#struct-576664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anjos L.</forename>
                    <surname>Macedo</surname>
                  </persName>
                  <idno type="halauthorid">2298559-0</idno>
                  <affiliation ref="#struct-486782"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12134</idno>
                <idno type="issn">0010-8545</idno>
                <idno type="eissn">0010-8545</idno>
                <title level="j">Coordination Chemistry Reviews</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">448</biblScope>
                  <biblScope unit="pp">214189</biblScope>
                  <date type="datePub">2021-12-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ccr.2021.214189</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Structure</term>
                <term xml:lang="en">Function</term>
                <term xml:lang="en">X-ray crystallography</term>
                <term xml:lang="en">NMR spectroscopy</term>
                <term xml:lang="en">SOUL protein</term>
                <term xml:lang="en">HEBP2</term>
                <term xml:lang="en">HEBP1</term>
              </keywords>
              <classCode scheme="halDomain" n="chim.coor">Chemical Sciences/Coordination chemistry</classCode>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The SOUL, or heme-binding protein HBP/SOUL, family represents a group of evolutionary conservedputative heme-binding proteins that contains a number of members in animal, plant and bacterial spe-cies. The structures of the murine form of HEBP1, or p22HBP, and the human form of HEBP2, or SOUL,have been determined in 2006 and 2011 respectively.In this work we discuss the structures of HEBP1 and HEBP2 in light of new X-ray data for heme boundmurine HEBP1. The interaction between tetrapyrroles and HEBP1, initially proven to be hydrophobic innature, was thought to also involve electrostatic interactions between heme propionate groups and pos-itively charged amino acid side chains. However, the new X-ray structure, and results from murine HEBP1variants and human HEBP1, confirm the hydrophobic nature of the heme-HEBP1 interaction, resulting inKdvalues in the low nanomolar range, and rules out any electrostatic stabilization. Results from NMRrelaxation time measurements for human HEBP1 describe a rigid globular protein with no change inmotional regime upon heme binding.X-ray structures deposited in the PDB for human HEBP2 are very similar to each other and to the newheme-bound murine HEBP1 X-ray structure (backbone rmsd ca. 1 Å). Results from a HSQC spectrum cen-tred on the histidine side chain Nd-proton region for HEBP2 confirm that HEBP2 does not bind heme viaH42 as no chemical shift differences were observed upon heme addition for backbone NH and Ndprotons.A survey of the functions attributed to HEBP1 and HEBP2 over the last 20 years span a wide range ofcellular pathways. Interestingly, many of them are specific to higher eukaryotes, particularly mammalsand a potential link between heme release under oxidative stress and human HEBP1 is also examinedusing recent data. However, at the present moment, trying to relate function to the involvement of hemehttps://doi.org/10.1016/j.ccr.2021.2141890010-8545/Ó2021 Elsevier B.V. All rights reserved.Abbreviations:HEBP1, Heme-binding protein 1 (or p22HBP); HEBP2, Heme-binding protein 2 (or SOUL); BH3, Bcl-2 homology 3; HSQC, heteronuclear single quantumcoherence spectroscopy; TROSY, transverse relaxation optimized spectroscopy; FQ, fluorescence quenching; PPIX, protoporphyrin IX; sGC, solubleGuanylyl Cyclase; hetNOE,heteronuclear nuclear Overhauser effect; rmsd, root mean squared deviation; BMRB, biological magnetic resonance bank; VAST, vector alignment search tool; MEL, murineerythroleukemia.⇑Corresponding authors.E-mail addresses:brian.goodfellow@ua.pt(B.J. Goodfellow),mdam@fct.unl(A.L. Macedo).Coordination Chemistry Reviews 448 (2021) 214189Contents lists available atScienceDirectCoordination Chemistry Reviewsjournal homepage: www.elsevier.com/locate/ccr</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1077985" status="INCOMING">
          <orgName>CICECO, Departamento de Química</orgName>
          <desc>
            <address>
              <addrLine>Universidade de Aveiro, 3810-193 Aveiro, Portugal</addrLine>
              <country key="PT"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-345590" status="VALID">
          <orgName>Instituto de Biologia Experimental e Tecnológica</orgName>
          <orgName type="acronym">IBET</orgName>
          <desc>
            <address>
              <addrLine>Av. RepúblicaQta. do Marquês2780-157 Oeiras</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.ibet.pt/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-140112" status="VALID">
          <orgName>Instituto de Tecnologia Química e Biológica António Xavier</orgName>
          <orgName type="acronym">ITQB</orgName>
          <desc>
            <address>
              <addrLine>Avenida da República Estação Agronómica Nacional 2780-157 Oeiras</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.itqb.unl.pt</ref>
          </desc>
          <listRelation>
            <relation active="#struct-327246" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-486782" status="VALID">
          <orgName>Unidade de Ciencias Biomoleculares Aplicadas</orgName>
          <orgName type="acronym">UCIBIO</orgName>
          <desc>
            <address>
              <addrLine>2829-516 Caparica, Portugal</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://www.requimte.pt/ucibio/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-156178" type="direct"/>
            <relation active="#struct-19144" type="indirect"/>
            <relation active="#struct-486781" type="indirect"/>
            <relation active="#struct-450840" type="indirect"/>
            <relation active="#struct-327246" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1077986" status="VALID">
          <orgName>GreenCoLab - Associação Oceano Verde, Universidade do Algarve</orgName>
          <desc>
            <address>
              <addrLine>Campus de Gambelas, Faro, Portugal</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://www.greencolab.com/greencolab-organization/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1061075" status="VALID">
          <orgName>Métaux et Organes</orgName>
          <orgName type="acronym">MET&amp;OR</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>17 rue des Martyrs 38054 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cbm-lab.fr/MetOr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043285" type="direct"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation name="UMR5249" active="#struct-441569" type="indirect"/>
            <relation name="DRF/IRIG/DIESE" active="#struct-555292" type="indirect"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-1043285" status="VALID">
          <idno type="IdRef">133878732</idno>
          <idno type="ISNI">0000000403840427</idno>
          <idno type="RNSR">200711914Z</idno>
          <idno type="ROR">https://ror.org/02dd25k08</idno>
          <orgName>Laboratoire de Chimie et Biologie des Métaux</orgName>
          <orgName type="acronym">LCBM - UMR 5249</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>17, rue des Martyrs 38054 Grenoble cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cbm-lab.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR5249" active="#struct-441569" type="direct"/>
            <relation name="DRF/IRIG/DIESE" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043297" status="VALID">
          <idno type="IdRef">184930839</idno>
          <idno type="RNSR">201119430B</idno>
          <orgName>Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée</orgName>
          <orgName type="acronym">LBFA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment B Biologie, 2280 Rue de la Piscine, 38400 Saint Martin d'Hères</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lbfa.univ-grenoble-alpes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1055" active="#struct-303623" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1077987" status="INCOMING">
          <orgName>Equity Analyst Biotech &amp; Healthcare</orgName>
          <desc>
            <address>
              <addrLine>Baader Helvea, Talstrasse, 98001 Zurich, Switzerland</addrLine>
              <country key="CH"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1042959" status="INCOMING">
          <orgName>Morsani College of Medicine [Tampa, USA]</orgName>
          <desc>
            <address>
              <addrLine>12901 Bruce B Downs Blvd, Tampa, FL 33612, États-Unis</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://health.usf.edu/medicine</ref>
          </desc>
          <listRelation>
            <relation active="#struct-306974" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-188849" status="VALID">
          <orgName>Center for Neuroscience and Cell Biology (CNC)</orgName>
          <orgName type="acronym">CNC</orgName>
          <desc>
            <address>
              <addrLine>Center for Neuroscience and Cell Biology University of Coimbra 3004-517 Coimbra</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.cnbc.pt/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300707" type="direct"/>
            <relation active="#struct-346951" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-576664" status="VALID">
          <orgName>Centre for Integrative Biology</orgName>
          <orgName type="acronym">CBI</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-93800" type="direct"/>
            <relation name="UMRS964" active="#struct-199013" type="indirect"/>
            <relation name="U1258" active="#struct-303623" type="indirect"/>
            <relation name="UMR7104" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-327246" status="VALID">
          <orgName>Universidade Nova de Lisboa = NOVA University Lisbon</orgName>
          <orgName type="acronym">NOVA</orgName>
          <desc>
            <address>
              <addrLine>Campus de Campolide1099-085 Lisboa</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.unl.pt/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-156178" status="VALID">
          <orgName>Requimte</orgName>
          <date type="start">2003-01-01</date>
          <desc>
            <address>
              <addrLine>Rua do Campo Alegre, 687;4169-007;Porto</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://www.requimte.pt/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-19144" type="direct"/>
            <relation active="#struct-486781" type="direct"/>
            <relation active="#struct-450840" type="indirect"/>
            <relation active="#struct-327246" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-19144" status="VALID">
          <orgName>Universidade do Porto = University of Porto</orgName>
          <date type="start">1911-01-01</date>
          <desc>
            <address>
              <addrLine>Praça de Gomes Teixeira, 4099-002 Porto</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://sigarra.up.pt/up/pt/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-486781" status="VALID">
          <orgName>Departamento de Química</orgName>
          <orgName type="acronym">DQ</orgName>
          <desc>
            <address>
              <addrLine>Campus da Caparica 2829-516 Caparica</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://www.dq.fct.unl.pt/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-450840" type="direct"/>
            <relation active="#struct-327246" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-450840" status="VALID">
          <orgName>Faculdade de Ciências e Tecnologia = School of Science &amp; Technology</orgName>
          <orgName type="acronym">FCT NOVA</orgName>
          <date type="start">1977-01-01</date>
          <desc>
            <address>
              <addrLine>Quinta da Torre, Campus Universitário, 2829-516 Caparica</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.fct.unl.pt/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-327246" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-306974" status="VALID">
          <idno type="ROR">https://ror.org/032db5x82</idno>
          <orgName>University of South Florida [Tampa]</orgName>
          <orgName type="acronym">USF</orgName>
          <desc>
            <address>
              <addrLine>4202 E. Fowler Avenue,  Tampa, FL 33620, USA</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.usf.edu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300707" status="VALID">
          <idno type="IdRef">026430339</idno>
          <idno type="ISNI">0000 0000 9511 4342</idno>
          <idno type="ROR">https://ror.org/04z8k9a98</idno>
          <idno type="Wikidata">Q368643</idno>
          <orgName>Universidade de Coimbra = University of Coimbra [Portugal]</orgName>
          <orgName type="acronym">UC</orgName>
          <date type="start">1290-01-01</date>
          <desc>
            <address>
              <addrLine>Rua LargaEdifício Faculdade de Medicina (R/Ch. Esq.)3004-504 Coimbra</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">http://www.uc.pt/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-346951" status="INCOMING">
          <orgName>Neuroscience Research Domain</orgName>
          <desc>
            <address>
              <country key="PT"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-93800" status="VALID">
          <idno type="IdRef">155263749</idno>
          <idno type="ISNI">0000 0004 0638 2716</idno>
          <idno type="RNSR">200112491C</idno>
          <idno type="ROR">https://ror.org/0015ws592</idno>
          <idno type="Wikidata">Q3152004</idno>
          <orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName>
          <orgName type="acronym">IGBMC</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igbmc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS964" active="#struct-199013" type="direct"/>
            <relation name="U1258" active="#struct-303623" type="direct"/>
            <relation name="UMR7104" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37796" status="VALID">
          <idno type="anr">ANR-10-IDEX-0002</idno>
          <idno type="program">Initiative d'excellence</idno>
          <orgName>UNISTRA</orgName>
          <desc>Par-delà les frontières, l'Université de Strasbourg</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-55006" status="VALID">
          <idno type="anr">ANR-10-LABX-0030</idno>
          <orgName>INRT</orgName>
          <desc>Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>