Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins - Archive ouverte HAL Access content directly
Journal Articles Journal of Proteome Research Year : 2021

Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins

Abstract

Much of our understanding of proteins and proteomes comes from the traditional protein structure-function paradigm. However, in the last two decades, both computational and experimental studies have provided evidence that a large fraction of functional proteomes across different domains of life consists of intrinsically disordered proteins thus triggering a quest to unravel and decipher protein intrinsic disorder. Unlike structured/ordered proteins, intrinsically disordered proteins/regions (IDPs/IDRs) do not possess a well-defined structure under physiological conditions, and exist as highly dynamic conformational ensembles. In spite of this peculiarity, these proteins have crucial roles in cell signaling and regulation. To date, studies on the abundance and function of IDPs/IDRs in viruses are rather limited. In order to fill this gap, we carried out an extensive and thorough bioinformatics analysis of 283,000 proteins from 6,108 reference viral proteomes. We analyzed protein intrinsic disorder from multiple perspectives, such as abundance of IDPs/IDRs across diverse virus types, their functional annotations, and subcellular localization in taxonomically divergent hosts. We show that the content of IDPs/IDRs in viral proteomes varies broadly as a function of virus genome types and
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Dates and versions

hal-03362325 , version 1 (01-10-2021)

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Naveen Kumar, Rahul Kaushik, Chandana Tennakoon, Vladimir N Uversky, Sonia Longhi, et al.. Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins. Journal of Proteome Research, 2021, 20 (5), pp.2704-2713. ⟨10.1021/acs.jproteome.1c00011⟩. ⟨hal-03362325⟩
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