Flow dearomatization of electron-poor 3-fluoromethylthioindoles by 1,3-dipolar cycloaddition
Résumé
Indoles substituted by electron-depleted thio groups at positions 1 and 3 react as C2=C3 dipolarophiles with an electron-rich azomethine ylide dipole under flow conditions. The dearomatizing (3+2) cycloadditions readily occur to afford the corresponding fluorinated 3Dpyrrolidinoindolines bearing a tetrasusbtituted carbon centre at the ring junction.
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