Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS Computational Biology Année : 2021

Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections

Résumé

Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.
Fichier principal
Vignette du fichier
BeneteauEtal2021.pdf (1.77 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03357550 , version 1 (28-09-2021)

Identifiants

Citer

Thomas Beneteau, Christian Selinger, Mircea T Sofonea, Samuel Alizon. Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections. PLoS Computational Biology, 2021, 17 (9), pp.e1009352. ⟨10.1371/journal.pcbi.1009352⟩. ⟨hal-03357550⟩
31 Consultations
62 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More