<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03355818</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T06:14:41+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports $Pseudomonas\ aeruginosa$-driven pathology</title>
            <author role="aut">
              <persName>
                <forename type="first">Salimata</forename>
                <surname>Bagayoko</surname>
              </persName>
              <idno type="idhal" notation="numeric">803490</idno>
              <idno type="halauthorid" notation="string">2064661-803490</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0956-4641</idno>
              <idno type="IDREF">https://www.idref.fr/263647560</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stephen Adonai</forename>
                <surname>Leon-Icaza</surname>
              </persName>
              <idno type="idhal" notation="numeric">810061</idno>
              <idno type="halauthorid" notation="string">2291616-810061</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7546-8228</idno>
              <idno type="IDREF">https://www.idref.fr/267447027</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Miriam</forename>
                <surname>Pinilla</surname>
              </persName>
              <idno type="idhal" notation="numeric">1289866</idno>
              <idno type="halauthorid" notation="string">2064664-1289866</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4317-7706</idno>
              <idno type="IDREF">https://www.idref.fr/272895237</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Hessel</surname>
              </persName>
              <email type="md5">1cf7943aa2a29bd710d99d0a8ebbdcf2</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">audrey-hessel</idno>
              <idno type="idhal" notation="numeric">1553317</idno>
              <idno type="halauthorid" notation="string">798281-1553317</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3489-4474</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karin</forename>
                <surname>Santoni</surname>
              </persName>
              <idno type="idhal" notation="numeric">1289872</idno>
              <idno type="halauthorid" notation="string">2064663-1289872</idno>
              <idno type="IDREF">https://www.idref.fr/271086823</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5688-9844</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Péricat</surname>
              </persName>
              <idno type="idhal" notation="numeric">1289876</idno>
              <idno type="halauthorid" notation="string">1422715-1289876</idno>
              <idno type="ORCID">https://orcid.org/0009-0001-0428-8211</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Jean</forename>
                <surname>Bordignon</surname>
              </persName>
              <idno type="idhal" notation="numeric">1382520</idno>
              <idno type="halauthorid" notation="string">2291617-1382520</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4073-8117</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Flavie</forename>
                <surname>Moreau</surname>
              </persName>
              <idno type="halauthorid">1681017-0</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elif</forename>
                <surname>Eren</surname>
              </persName>
              <idno type="halauthorid">1803451-0</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurelien</forename>
                <surname>Boyance</surname>
              </persName>
              <idno type="idhal" notation="numeric">1285926</idno>
              <idno type="halauthorid" notation="string">2903394-1285926</idno>
              <idno type="IDREF">https://www.idref.fr/264312104</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuelle</forename>
                <surname>Naser</surname>
              </persName>
              <idno type="halauthorid">2291619-0</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lise</forename>
                <surname>Lefèvre</surname>
              </persName>
              <idno type="halauthorid">518713-0</idno>
              <affiliation ref="#struct-1062050"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Berrone</surname>
              </persName>
              <idno type="halauthorid">1678772-0</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nino</forename>
                <surname>Iakobachvili</surname>
              </persName>
              <idno type="idhal" notation="numeric">808946</idno>
              <idno type="halauthorid" notation="string">2291620-808946</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0797-2665</idno>
              <affiliation ref="#struct-83832"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Metais</surname>
              </persName>
              <idno type="idhal" notation="numeric">1251734</idno>
              <idno type="halauthorid" notation="string">1422910-1251734</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9538-0338</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yoann</forename>
                <surname>Rombouts</surname>
              </persName>
              <email type="md5">849358c06282e7d1664b52ba5dc09e0c</email>
              <email type="domain">ipbs.fr</email>
              <idno type="idhal" notation="string">yoann-rombouts</idno>
              <idno type="idhal" notation="numeric">739107</idno>
              <idno type="halauthorid" notation="string">10194-739107</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4482-2199</idno>
              <idno type="IDREF">https://www.idref.fr/153100370</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Geanncarlo</forename>
                <surname>Lugo-Villarino</surname>
              </persName>
              <email type="md5">a02dbe850f6bff7fe835a442aac37f5a</email>
              <email type="domain">ipbs.fr</email>
              <idno type="idhal" notation="string">geanncarlo-lugo</idno>
              <idno type="idhal" notation="numeric">178174</idno>
              <idno type="halauthorid" notation="string">14605-178174</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-4674-2019</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4620-8491</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=dtRP9msAAAAJ&amp;hl=en</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-4674-2019</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Agnès</forename>
                <surname>Coste</surname>
              </persName>
              <email type="md5">a471f9498fd61e114c708da38fd56705</email>
              <email type="domain">univ-tlse3.fr</email>
              <idno type="idhal" notation="numeric">975739</idno>
              <idno type="halauthorid" notation="string">990337-975739</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7781-3323</idno>
              <idno type="IDREF">https://www.idref.fr/076780112</idno>
              <affiliation ref="#struct-1062050"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ina</forename>
                <surname>Attrée</surname>
              </persName>
              <email type="md5">79b1316d3811c80ce5aa9072b6d32529</email>
              <email type="domain">ibs.fr</email>
              <idno type="idhal" notation="string">ina-attree</idno>
              <idno type="idhal" notation="numeric">182977</idno>
              <idno type="halauthorid" notation="string">44988-182977</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2580-764X</idno>
              <idno type="IDREF">https://www.idref.fr/200670530</idno>
              <idno type="IDREF">https://www.idref.fr/087253461</idno>
              <affiliation ref="#struct-1057997"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dara</forename>
                <forename type="middle">W.</forename>
                <surname>Frank</surname>
              </persName>
              <idno type="halauthorid">2292633-0</idno>
              <affiliation ref="#struct-572475"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hans</forename>
                <surname>Clevers</surname>
              </persName>
              <idno type="idhal" notation="numeric">759649</idno>
              <idno type="halauthorid" notation="string">306695-759649</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3077-5582</idno>
              <affiliation ref="#struct-528154"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Peter</forename>
                <forename type="middle">J.</forename>
                <surname>Peters</surname>
              </persName>
              <idno type="halauthorid">2292634-0</idno>
              <affiliation ref="#struct-83832"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Cougoule</surname>
              </persName>
              <email type="md5">7ca154105217358516e0275586090d1e</email>
              <email type="domain">ipbs.fr</email>
              <idno type="idhal" notation="string">celine-cougoule</idno>
              <idno type="idhal" notation="numeric">742411</idno>
              <idno type="halauthorid" notation="string">5302-742411</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6795-5448</idno>
              <idno type="IDREF">https://www.idref.fr/076725073</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rémi</forename>
                <surname>Planès</surname>
              </persName>
              <email type="md5">7eea28d817c2b26fee17fa1c6a0816c6</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1152087</idno>
              <idno type="halauthorid" notation="string">785228-1152087</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8612-3065</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3695-3965</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Etienne</forename>
                <surname>Meunier</surname>
              </persName>
              <email type="md5">45633f5eaae792c08aa51f2db6ba19a0</email>
              <email type="domain">ipbs.fr</email>
              <idno type="idhal" notation="numeric">769163</idno>
              <idno type="halauthorid" notation="string">731129-769163</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3651-4877</idno>
              <idno type="IDREF">https://www.idref.fr/171641698</idno>
              <affiliation ref="#struct-583"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ina</forename>
                <surname>ATTREE</surname>
              </persName>
              <email type="md5">79b1316d3811c80ce5aa9072b6d32529</email>
              <email type="domain">ibs.fr</email>
            </editor>
            <funder ref="#projanr-48162"/>
            <funder ref="#projanr-42987"/>
            <funder ref="#projeurop-713952"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-09-28 15:37:19</date>
              <date type="whenModified">2026-05-12 03:18:24</date>
              <date type="whenReleased">2021-09-28 15:57:04</date>
              <date type="whenProduced">2021</date>
              <date type="whenEndEmbargoed">2021-09-28</date>
              <ref type="file" target="https://hal.science/hal-03355818v1/document">
                <date notBefore="2021-09-28"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-03355818v1/file/bagay1.pdf" id="file-3356979-2944711">
                <date notBefore="2021-09-28"/>
              </ref>
              <ref type="externalLink" target="https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009927&amp;type=printable"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="131294">
                <persName>
                  <forename>Ina</forename>
                  <surname>ATTREE</surname>
                </persName>
                <email type="md5">79b1316d3811c80ce5aa9072b6d32529</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03355818</idno>
            <idno type="halUri">https://hal.science/hal-03355818</idno>
            <idno type="halBibtex">bagayoko:hal-03355818</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS Pathogens&lt;/i&gt;, 2021, 17 (9), pp.e1009927. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.ppat.1009927"&gt;&amp;#x27E8;10.1371/journal.ppat.1009927&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS Pathogens, 2021, 17 (9), pp.e1009927. &amp;#x27E8;10.1371/journal.ppat.1009927&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3356979-2944711"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="IBS" corresp="CEA">Institut de Biologie Structurale</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="IPBS">Institut de Pharmacologie et de Biologie Structurale</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="IBS-PBRC" corresp="IBS">Groupe Imagerie intégrée de la réponse au stress / Bacterial Pathogenesis and Cellular Responses Group (IBS-PBRC)</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="RESTORE">RESTORE</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES">Académie des sciences</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-3" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 3)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports $Pseudomonas\ aeruginosa$-driven pathology</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Salimata</forename>
                    <surname>Bagayoko</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">803490</idno>
                  <idno type="halauthorid" notation="string">2064661-803490</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0956-4641</idno>
                  <idno type="IDREF">https://www.idref.fr/263647560</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stephen Adonai</forename>
                    <surname>Leon-Icaza</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">810061</idno>
                  <idno type="halauthorid" notation="string">2291616-810061</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7546-8228</idno>
                  <idno type="IDREF">https://www.idref.fr/267447027</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Miriam</forename>
                    <surname>Pinilla</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1289866</idno>
                  <idno type="halauthorid" notation="string">2064664-1289866</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4317-7706</idno>
                  <idno type="IDREF">https://www.idref.fr/272895237</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Hessel</surname>
                  </persName>
                  <email type="md5">1cf7943aa2a29bd710d99d0a8ebbdcf2</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">audrey-hessel</idno>
                  <idno type="idhal" notation="numeric">1553317</idno>
                  <idno type="halauthorid" notation="string">798281-1553317</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3489-4474</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karin</forename>
                    <surname>Santoni</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1289872</idno>
                  <idno type="halauthorid" notation="string">2064663-1289872</idno>
                  <idno type="IDREF">https://www.idref.fr/271086823</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5688-9844</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Péricat</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1289876</idno>
                  <idno type="halauthorid" notation="string">1422715-1289876</idno>
                  <idno type="ORCID">https://orcid.org/0009-0001-0428-8211</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Jean</forename>
                    <surname>Bordignon</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1382520</idno>
                  <idno type="halauthorid" notation="string">2291617-1382520</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4073-8117</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Flavie</forename>
                    <surname>Moreau</surname>
                  </persName>
                  <idno type="halauthorid">1681017-0</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elif</forename>
                    <surname>Eren</surname>
                  </persName>
                  <idno type="halauthorid">1803451-0</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurelien</forename>
                    <surname>Boyance</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1285926</idno>
                  <idno type="halauthorid" notation="string">2903394-1285926</idno>
                  <idno type="IDREF">https://www.idref.fr/264312104</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuelle</forename>
                    <surname>Naser</surname>
                  </persName>
                  <idno type="halauthorid">2291619-0</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lise</forename>
                    <surname>Lefèvre</surname>
                  </persName>
                  <idno type="halauthorid">518713-0</idno>
                  <affiliation ref="#struct-1062050"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Berrone</surname>
                  </persName>
                  <idno type="halauthorid">1678772-0</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nino</forename>
                    <surname>Iakobachvili</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">808946</idno>
                  <idno type="halauthorid" notation="string">2291620-808946</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0797-2665</idno>
                  <affiliation ref="#struct-83832"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Metais</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1251734</idno>
                  <idno type="halauthorid" notation="string">1422910-1251734</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9538-0338</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoann</forename>
                    <surname>Rombouts</surname>
                  </persName>
                  <email type="md5">849358c06282e7d1664b52ba5dc09e0c</email>
                  <email type="domain">ipbs.fr</email>
                  <idno type="idhal" notation="string">yoann-rombouts</idno>
                  <idno type="idhal" notation="numeric">739107</idno>
                  <idno type="halauthorid" notation="string">10194-739107</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4482-2199</idno>
                  <idno type="IDREF">https://www.idref.fr/153100370</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Geanncarlo</forename>
                    <surname>Lugo-Villarino</surname>
                  </persName>
                  <email type="md5">a02dbe850f6bff7fe835a442aac37f5a</email>
                  <email type="domain">ipbs.fr</email>
                  <idno type="idhal" notation="string">geanncarlo-lugo</idno>
                  <idno type="idhal" notation="numeric">178174</idno>
                  <idno type="halauthorid" notation="string">14605-178174</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-4674-2019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4620-8491</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=dtRP9msAAAAJ&amp;hl=en</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-4674-2019</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Agnès</forename>
                    <surname>Coste</surname>
                  </persName>
                  <email type="md5">a471f9498fd61e114c708da38fd56705</email>
                  <email type="domain">univ-tlse3.fr</email>
                  <idno type="idhal" notation="numeric">975739</idno>
                  <idno type="halauthorid" notation="string">990337-975739</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7781-3323</idno>
                  <idno type="IDREF">https://www.idref.fr/076780112</idno>
                  <affiliation ref="#struct-1062050"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ina</forename>
                    <surname>Attrée</surname>
                  </persName>
                  <email type="md5">79b1316d3811c80ce5aa9072b6d32529</email>
                  <email type="domain">ibs.fr</email>
                  <idno type="idhal" notation="string">ina-attree</idno>
                  <idno type="idhal" notation="numeric">182977</idno>
                  <idno type="halauthorid" notation="string">44988-182977</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2580-764X</idno>
                  <idno type="IDREF">https://www.idref.fr/200670530</idno>
                  <idno type="IDREF">https://www.idref.fr/087253461</idno>
                  <affiliation ref="#struct-1057997"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dara</forename>
                    <forename type="middle">W.</forename>
                    <surname>Frank</surname>
                  </persName>
                  <idno type="halauthorid">2292633-0</idno>
                  <affiliation ref="#struct-572475"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hans</forename>
                    <surname>Clevers</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">759649</idno>
                  <idno type="halauthorid" notation="string">306695-759649</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3077-5582</idno>
                  <affiliation ref="#struct-528154"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peter</forename>
                    <forename type="middle">J.</forename>
                    <surname>Peters</surname>
                  </persName>
                  <idno type="halauthorid">2292634-0</idno>
                  <affiliation ref="#struct-83832"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Cougoule</surname>
                  </persName>
                  <email type="md5">7ca154105217358516e0275586090d1e</email>
                  <email type="domain">ipbs.fr</email>
                  <idno type="idhal" notation="string">celine-cougoule</idno>
                  <idno type="idhal" notation="numeric">742411</idno>
                  <idno type="halauthorid" notation="string">5302-742411</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6795-5448</idno>
                  <idno type="IDREF">https://www.idref.fr/076725073</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rémi</forename>
                    <surname>Planès</surname>
                  </persName>
                  <email type="md5">7eea28d817c2b26fee17fa1c6a0816c6</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1152087</idno>
                  <idno type="halauthorid" notation="string">785228-1152087</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8612-3065</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3695-3965</idno>
                  <affiliation ref="#struct-583"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Etienne</forename>
                    <surname>Meunier</surname>
                  </persName>
                  <email type="md5">45633f5eaae792c08aa51f2db6ba19a0</email>
                  <email type="domain">ipbs.fr</email>
                  <idno type="idhal" notation="numeric">769163</idno>
                  <idno type="halauthorid" notation="string">731129-769163</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3651-4877</idno>
                  <idno type="IDREF">https://www.idref.fr/171641698</idno>
                  <affiliation ref="#struct-583"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">1959</idno>
                <idno type="issn">1553-7366</idno>
                <idno type="eissn">1553-7374</idno>
                <title level="j">PLoS Pathogens</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">17</biblScope>
                  <biblScope unit="issue">9</biblScope>
                  <biblScope unit="pp">e1009927</biblScope>
                  <date type="datePub">2021</date>
                  <date type="dateEpub">2021-09-13</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.ppat.1009927</idno>
              <ref type="publisher">https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009927</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mp.bac">Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. $Pseudomonas\ aeruginosa$ expresses a phospholipase, ExoU that triggers pathological host cell necrosis through a poorly characterized pathway. Here, we investigated the molecular and cellular mechanisms of ExoU-mediated necrosis. We show that cellular peroxidised phospholipids enhance ExoU phospholipase activity, which drives necrosis of immune and non-immune cells. Conversely, both the endogenous lipid peroxidation regulator GPX4 and the pharmacological inhibition of lipid peroxidation delay ExoU-dependent cell necrosis and improve bacterial elimination in vitro and in vivo . Our findings also pertain to the ExoU-related phospholipase from the bacterial pathogen $Burkholderia\ thailandensis$ , suggesting that exploitation of peroxidised phospholipids might be a conserved virulence mechanism among various microbial phospholipases. Overall, our results identify an original lipid peroxidation-based virulence mechanism as a strong contributor of microbial phospholipase-driven pathology.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-583" status="OLD">
          <idno type="IdRef">035430109</idno>
          <idno type="ISNI">0000 0000 9679 268X</idno>
          <idno type="RNSR">199911775H</idno>
          <idno type="ROR">https://ror.org/016zvc994</idno>
          <idno type="Wikidata">Q18214944</idno>
          <orgName>Institut de pharmacologie et de biologie structurale</orgName>
          <orgName type="acronym">IPBS</orgName>
          <date type="start">1996-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ipbs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR5089" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1062050" status="OLD">
          <idno type="IdRef">252908295</idno>
          <idno type="RNSR">202123705E</idno>
          <orgName>Geroscience and rejuvenation research center</orgName>
          <orgName type="acronym">RESTORE</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>4 bis av. Hubert Curien, Bat INCERE, 31100 TOULOUSE</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-199980" type="direct"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="U1301" active="#struct-303623" type="direct"/>
            <relation name="UMR5070" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-83832" status="VALID">
          <idno type="ROR">https://ror.org/02jz4aj89</idno>
          <orgName>Maastricht University [Maastricht]</orgName>
          <desc>
            <address>
              <addrLine>Universiteitssingel 40;6200 MD Maastricht</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.maastrichtuniversity.nl/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1057997" status="VALID">
          <orgName>Groupe Pathogenèse Bactérienne et Réponses Cellulaires / Bacterial Pathogenesis and Cellular Responses Group</orgName>
          <orgName type="acronym">IBS-PBRC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>71 Avenue des Martyrs 38000 Grenoble</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ibs.fr/recherche/groupes-de-recherche/groupe-pathogenese-bacterienne-et-reponses-cellulaires-ina-attree/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043235" type="direct"/>
            <relation name="UMR5075" active="#struct-441569" type="indirect"/>
            <relation name="DRF/IRIG/DBSC" active="#struct-555292" type="indirect"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-572475" status="VALID">
          <orgName>Medical College of Wisconsin [Milwaukee]</orgName>
          <orgName type="acronym">MCW</orgName>
          <desc>
            <address>
              <addrLine>8701 W Watertown Plank Rd, Wauwatosa, WI 53226, États-Unis</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.mcw.edu/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-528154" status="VALID">
          <orgName>Hubrecht Institute [Utrecht, Netherlands]</orgName>
          <desc>
            <address>
              <addrLine>Uppsalalaan 8, 3584 CT Utrecht.</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.hubrecht.eu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-73956" type="direct"/>
            <relation active="#struct-444582" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-199980" status="VALID">
          <orgName>Établissement Français du Sang [La Plaine Saint-Denis]</orgName>
          <orgName type="acronym">EFS</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>20 Avenue du Stade de France 93218 La Plaine Saint Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.dondusang.net</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-1043235" status="VALID">
          <idno type="IdRef">06912633X</idno>
          <idno type="ISNI">0000 0004 0641 5776</idno>
          <idno type="RNSR">199911764W</idno>
          <idno type="ROR">https://ror.org/04szabx38</idno>
          <orgName>Institut de biologie structurale</orgName>
          <orgName type="acronym">IBS - UMR 5075</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Institut de Biologie Structurale, 71 avenue des martyrs, CS 10090, 38044 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR5075" active="#struct-441569" type="direct"/>
            <relation name="DRF/IRIG/DBSC" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-73956" status="VALID">
          <idno type="ROR">https://ror.org/0575yy874</idno>
          <orgName>University Medical Center [Utrecht]</orgName>
          <orgName type="acronym">UMCU</orgName>
          <desc>
            <address>
              <addrLine>Heidelberglaan 1003584 CX Utrecht</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.umcutrecht.nl/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-444582" status="VALID">
          <orgName>Royal Netherlands Academy of Arts and Sciences</orgName>
          <orgName type="acronym">KNAW</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-48162" status="VALID">
          <idno type="anr">ANR-18-CE14-0007</idno>
          <idno type="program">APPEL À PROJETS GÉNÉRIQUE 2018</idno>
          <orgName>ENDIABAC</orgName>
          <desc>LE SYSTEME NERVEUX ENTERIQUE COMME CIBLE POUR TRAITER LE DIABETE DE TYPE 2 : ROLES DES LIPIDES BIOACTIFS BACTERIENS</desc>
          <date type="start">2018</date>
        </org>
        <org type="anrProject" xml:id="projanr-42987" status="VALID">
          <idno type="anr">ANR-17-CE11-0006</idno>
          <orgName>MacGlycoTB</orgName>
          <desc>Rôle de ST8SIA4 et de la polysialylation des protéines des macrophages dans la réponse immunitaire contre une infection par Mycobacterium tuberculosis</desc>
          <date type="start">2017</date>
        </org>
        <org type="europeanProject" xml:id="projeurop-713952" status="VALID">
          <idno type="number">804249</idno>
          <idno type="program">ERC-2018-STG</idno>
          <idno type="call">ERC-2018-STG</idno>
          <orgName>INFLAME</orgName>
          <desc>Deciphering the host and microbial grounds that license inflammasome-mediated execution</desc>
          <date type="start">2018-12-01</date>
          <date type="end">2023-11-30</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>