Background: Tropical coral reefs cover ca. 0.1% of the Earth's surface but host an outstanding biodiversity and provide important ecosystem services to millions of people living nearby. They are currently threatened by local stressors (e.g. nutrient enrichment and chemical pollution arising from poor land management, sewage effluents, agriculture, industry) and global stressors (mainly seawater warming and acidification, i.e. climate change). Global and local stressors interact in different ways, but the presence of one stressor often reduces the tolerance to additional stress. While global stressors cannot be mitigated solely by local actions, local stressors can be reduced through ecosystem management, therefore minimizing the impact of climate change on coral reefs. We systematically mapped the evidence of impacts of chemicals arising from anthropogenic activities on tropical reef-building corals, which are the main engineer species of reef ecosystems, to inform decision-makers on the available evidence on this topic. Methods: We searched the relevant literature using English terms combined in a tested search string in two publication databases (Scopus and Web Of Science Core Collection). The search string combined terms describing the population (tropical reef-building corals) and the exposure (chemicals). We searched for additional literature through three search engines, three dissertations repositories, 11 specialist websites, and through a call to local stakeholders. Titles, abstracts, and full-texts were successively screened using pre-defned eligibility criteria. A database of all studies included in the map with coded metadata was produced. The evidence was described and knowledge clusters and gaps were identifed through the distribution and frequency of studies into types of exposure and/or types of outcomes and/or types of study. Review findings: The initial searches identifed 23,403 articles which resulted in 15,177 articles after duplicate removal. Among them, 908 articles were retained after screening process, corresponding to 7937 studies (a study being the combination of a taxon, an exposure, and an outcome). Among these studies, 30.5% dealt with the impact of nutrient enrichment on corals while 25% concerned the impact of human activities without reference to a chemical. The most measured outcomes were those related to the chemical concentration in corals (bioaccumulation, 25.8%), to coral physiology (16.9%), cover (14%), and mortality (9%). Half of the studies (48.4%) were experimental—the exposure was controlled by the researchers—and were conducted in laboratory conditions (39.4%) and in situ (9%). The most studied taxa, exposure, and outcomes were diferent between experimental and observational studies. Conclusions: We identifed four well-represented subtopics that may be amenable to relevant full syntheses via systematic reviews: (1) evidence on bioaccumulation of chemicals by corals; (2) evidence on the efects of nutrient enrichment on corals; (3) evidence on the efects of human activities on corals; and (4) evidence on the ecotoxicological efects of chemicals on corals (except nutrient enrichment). The systematic map shows that corals in their natural environment can be exposed to many categories of chemicals, and that there is a complete gap in experimental research on the combined efects of more than two categories of chemicals. We therefore encourage research on this topic.