Biodegradation of metal-based ultra-small nanoparticles: A combined approach using TDA-ICP-MS and CE-ICP-MS

The knowledge of the fate of metal-containing nanoparticles in biological media in aqueous media is of utmost importance for the future use of these promising theranostic agents for clinical applications. A methodology based on the combination of TDA-ICP-MS and CE-ICP-MS was applied to study the degradation pathway of AGuIX, a phase 2 clinical ultrasmall gadolinium-containing nanoparticle. Nanoparticle size measurements and gadolinium speciation performed in different media (phosphate buffer, urine and serum) demonstrated an accelerated dissolution of AGuIX in serum, without any release of free gadolinium for each medium.

Mots clés

Ultrasmall nanoparticles Gadolinium containing drug Taylor dispersion analysis Inductively coupled plasma mass spectrometry Capillary electrophoresis Biodegradation

Domaines

Matériaux Chimie analytique

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2021_AnalyticaChimicActa_Biodegradation-metal-based-ultra-small-nanoparticles.pdf (1.5 Mo)

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https://hal.science/hal-03352486

Soumis le : jeudi 23 septembre 2021-11:33:45

Dernière modification le : lundi 15 avril 2024-11:25:23

Archivage à long terme le : vendredi 24 décembre 2021-19:37:27

Dates et versions

hal-03352486 , version 1 (23-09-2021)

Identifiants

HAL Id : hal-03352486 , version 1
DOI : 10.1016/j.aca.2021.339081

Citer

Lucie Labied, Paul Rocchi, Tristan Doussineau, Jérôme Randon, Olivier Tillement, et al.. Biodegradation of metal-based ultra-small nanoparticles: A combined approach using TDA-ICP-MS and CE-ICP-MS. Analytica Chimica Acta, 2021, 1185, pp.339081. ⟨10.1016/j.aca.2021.339081⟩. ⟨hal-03352486⟩

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