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Article Dans Une Revue Analytica Chimica Acta Année : 2021

Biodegradation of metal-based ultra-small nanoparticles: A combined approach using TDA-ICP-MS and CE-ICP-MS

Résumé

The knowledge of the fate of metal-containing nanoparticles in biological media in aqueous media is of utmost importance for the future use of these promising theranostic agents for clinical applications. A methodology based on the combination of TDA-ICP-MS and CE-ICP-MS was applied to study the degradation pathway of AGuIX, a phase 2 clinical ultrasmall gadolinium-containing nanoparticle. Nanoparticle size measurements and gadolinium speciation performed in different media (phosphate buffer, urine and serum) demonstrated an accelerated dissolution of AGuIX in serum, without any release of free gadolinium for each medium.
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Dates et versions

hal-03352486 , version 1 (23-09-2021)

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Lucie Labied, Paul Rocchi, Tristan Doussineau, Jérôme Randon, Olivier Tillement, et al.. Biodegradation of metal-based ultra-small nanoparticles: A combined approach using TDA-ICP-MS and CE-ICP-MS. Analytica Chimica Acta, 2021, 1185, pp.339081. ⟨10.1016/j.aca.2021.339081⟩. ⟨hal-03352486⟩
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