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Article Dans Une Revue Angewandte Chemie International Edition Année : 2021

Doxorubicin‐sensitized Luminescence of NIR‐emitting Ytterbium Liposomes: Towards Direct Monitoring of Drug Release

S. Lacerda
Anthony Delalande
Agnes A. Pallier
Celia ́ Bonnet
Frédéric Szeremeta
Sandra Même
Chantal Pichon
Stephane Petoud
Éva Tóth

Résumé

Drug-loaded liposomes are typical examples of nanomedicine. We show here that doxorubicin, the anti-cancer agent in the liposomal drug Doxil ® , can sensitize Ytterbium (Yb 3+ ) and generate its near infrared (NIR) emission. When doxorubicin and amphiphilic Yb 3+ chelates are incorporated into liposomes, the sensitized emission of Yb 3+ is dependent on the integrity of the particles which can be used to monitor drug release. We also established the first demonstration that the NIR Yb 3+ emission signal is observable in living mice following intratumoral injection of the Yb 3+ -doxorubicin-liposomes, using a commercial macroscopic setup equipped with a near-infrared camera.
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Dates et versions

hal-03349106 , version 1 (18-11-2021)

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Citer

S. Lacerda, Anthony Delalande, Svetlana V. Eliseeva, Agnes A. Pallier, Celia ́ Bonnet, et al.. Doxorubicin‐sensitized Luminescence of NIR‐emitting Ytterbium Liposomes: Towards Direct Monitoring of Drug Release. Angewandte Chemie International Edition, 2021, 60 (44), pp.23574-23577. ⟨10.1002/anie.202109408⟩. ⟨hal-03349106⟩
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