Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? - Archive ouverte HAL Access content directly
Journal Articles NeuroImage Year : 2021

Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?

Kurt G Schilling , François Rheault (1) , Laurent Petit (2) , Colin B Hansen , Vishwesh Nath , Fang-Cheng Yeh , Gabriel Girard , Muhamed Barakovic , Jonathan Rafael-Patino , Thomas Yu , Elda Fischi-Gomez , Marco Pizzolato , Mario Ocampo-Pineda , Simona Schiavi , Erick J Canales-Rodríguez , Alessandro Daducci , Cristina Granziera , Giorgio Innocenti , Jean-Philippe Thiran , Laura Mancini , Stephen Wastling , Sirio Cocozza , Maria Petracca , Giuseppe Pontillo , Matteo Mancini , Sjoerd B Vos , Vejay N Vakharia , John S Duncan , Helena Melero , Lidia Manzanedo , Emilio Sanz-Morales , Ángel Peña-Melián , Fernando Calamante , Arnaud Attyé , Ryan P Cabeen , Laura Korobova , Arthur W Toga , Anupa Ambili Vijayakumari , Drew Parker , Ragini Verma , Ahmed Radwan , Stefan Sunaert , Louise Emsell , Alberto de Luca , Alexander Leemans , Claude J Bajada , Hamied Haroon , Hojjatollah Azadbakht , Maxime Chamberland , Sila Genc , Chantal M W Tax , Ping-Hong Yeh , Rujirutana Srikanchana , Colin D Mcknight , Joseph Yuan-Mou Yang , Jian Chen , Claire E Kelly , Chun-Hung Yeh , Jerome Cochereau , Jerome J Maller , Thomas Welton , Fabien Almairac (3, 4) , Kiran K Seunarine , Chris A Clark , Fan Zhang , Nikos Makris , Alexandra Golby , Yogesh Rathi , Lauren J O'Donnell , Yihao Xia , Dogu Baran Aydogan , Yonggang Shi , Francisco Guerreiro Fernandes , Mathijs Raemaekers , Shaun Warrington , Stijn Michielse , Alonso Ramírez-Manzanares , Luis Concha , Ramón Aranda , Mariano Rivera Meraz , Garikoitz Lerma-Usabiaga , Lucas Roitman , Lucius S Fekonja , Navona Calarco , Michael Joseph , Hajer Nakua , Aristotle N Voineskos , Philippe Karan , Gabrielle Grenier , Jon Haitz Legarreta , Nagesh Adluru , Veena A Nair , Vivek Prabhakaran , Andrew L Alexander , Koji Kamagata , Yuya Saito , Wataru Uchida , Christina Andica , Masahiro Abe , Roza G Bayrak , Claudia a M Gandini Wheeler-Kingshott , Egidio d'Angelo , Fulvia Palesi , Giovanni Savini , Nicolò Rolandi , Pamela Guevara , Josselin Houenou , Narciso López-López , Jean-François Mangin (5) , Cyril Poupon , Claudio Román , Andrea Vázquez , Chiara Maffei , Mavilde Arantes , José Paulo Andrade , Susana Maria Silva , Vince D Calhoun , Eduardo Caverzasi , Simone Sacco , Michael Lauricella , Franco Pestilli , Daniel Bullock , Yang Zhan , Edith Brignoni-Perez , Catherine Lebel , Jess E Reynolds , Igor Nestrasil , René Labounek , Christophe Lenglet , Amy Paulson , Stefania Aulicka , Sarah R Heilbronner , Katja Heuer (6) , Bramsh Qamar Chandio , Javier Guaje , Wei Tang , Eleftherios Garyfallidis , Rajikha Raja , Adam W Anderson , Bennett A Landman , Maxime Descoteaux (1)
Kurt G Schilling
  • Function : Author
  • PersonId : 1110413
Laurent Petit
Colin B Hansen
  • Function : Author
Vishwesh Nath
  • Function : Author
Fang-Cheng Yeh
  • Function : Author
Gabriel Girard
  • Function : Author
  • PersonId : 771524
  • IdRef : 193861070
Muhamed Barakovic
  • Function : Author
Jonathan Rafael-Patino
  • Function : Author
Thomas Yu
  • Function : Author
Elda Fischi-Gomez
  • Function : Author
Marco Pizzolato
  • Function : Author
Mario Ocampo-Pineda
  • Function : Author
Simona Schiavi
  • Function : Author
Erick J Canales-Rodríguez
  • Function : Author
Alessandro Daducci
  • Function : Author
Cristina Granziera
  • Function : Author
Giorgio Innocenti
  • Function : Author
Jean-Philippe Thiran
  • Function : Author
Laura Mancini
  • Function : Author
Stephen Wastling
  • Function : Author
Sirio Cocozza
Maria Petracca
Giuseppe Pontillo
  • Function : Author
Matteo Mancini
  • Function : Author
Sjoerd B Vos
  • Function : Author
Vejay N Vakharia
  • Function : Author
John S Duncan
  • Function : Author
Helena Melero
  • Function : Author
Lidia Manzanedo
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Emilio Sanz-Morales
  • Function : Author
Ángel Peña-Melián
  • Function : Author
Fernando Calamante
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Arnaud Attyé
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Ryan P Cabeen
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Laura Korobova
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Arthur W Toga
  • Function : Author
Anupa Ambili Vijayakumari
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Drew Parker
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Ragini Verma
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Ahmed Radwan
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Stefan Sunaert
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Louise Emsell
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Alberto de Luca
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Alexander Leemans
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Claude J Bajada
  • Function : Author
Hamied Haroon
  • Function : Author
Hojjatollah Azadbakht
  • Function : Author
Maxime Chamberland
  • Function : Author
Sila Genc
  • Function : Author
Chantal M W Tax
Ping-Hong Yeh
  • Function : Author
Rujirutana Srikanchana
  • Function : Author
Colin D Mcknight
  • Function : Author
Joseph Yuan-Mou Yang
  • Function : Author
Jian Chen
Claire E Kelly
  • Function : Author
Chun-Hung Yeh
  • Function : Author
Jerome Cochereau
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Jerome J Maller
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Thomas Welton
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Kiran K Seunarine
  • Function : Author
Chris A Clark
  • Function : Author
Fan Zhang
Nikos Makris
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Alexandra Golby
  • Function : Author
Yogesh Rathi
  • Function : Author
Lauren J O'Donnell
  • Function : Author
Yihao Xia
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Dogu Baran Aydogan
  • Function : Author
Yonggang Shi
  • Function : Author
Francisco Guerreiro Fernandes
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Mathijs Raemaekers
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Shaun Warrington
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Stijn Michielse
  • Function : Author
Alonso Ramírez-Manzanares
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Luis Concha
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Ramón Aranda
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Mariano Rivera Meraz
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Garikoitz Lerma-Usabiaga
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Lucas Roitman
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Lucius S Fekonja
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Navona Calarco
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Michael Joseph
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Hajer Nakua
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Aristotle N Voineskos
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Philippe Karan
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Gabrielle Grenier
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Jon Haitz Legarreta
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Nagesh Adluru
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Veena A Nair
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Vivek Prabhakaran
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Andrew L Alexander
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Koji Kamagata
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Yuya Saito
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Wataru Uchida
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Christina Andica
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Masahiro Abe
  • Function : Author
Roza G Bayrak
  • Function : Author
Egidio d'Angelo
  • Function : Author
Fulvia Palesi
  • Function : Author
Giovanni Savini
  • Function : Author
Nicolò Rolandi
  • Function : Author
Pamela Guevara
  • Function : Author
Josselin Houenou
Narciso López-López
  • Function : Author
Cyril Poupon
  • Function : Author
Claudio Román
  • Function : Author
Andrea Vázquez
  • Function : Author
Chiara Maffei
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Mavilde Arantes
  • Function : Author
José Paulo Andrade
  • Function : Author
Susana Maria Silva
  • Function : Author
Vince D Calhoun
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Eduardo Caverzasi
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Simone Sacco
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Michael Lauricella
  • Function : Author
Franco Pestilli
Daniel Bullock
  • Function : Author
Yang Zhan
  • Function : Author
Edith Brignoni-Perez
  • Function : Author
Catherine Lebel
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Jess E Reynolds
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Igor Nestrasil
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René Labounek
  • Function : Author
Christophe Lenglet
  • Function : Author
Amy Paulson
  • Function : Author
Stefania Aulicka
  • Function : Author
Sarah R Heilbronner
  • Function : Author
Katja Heuer
  • Function : Author
  • PersonId : 1076007
  • IdHAL : katja-heuer
Bramsh Qamar Chandio
  • Function : Author
Javier Guaje
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Wei Tang
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Eleftherios Garyfallidis
  • Function : Author
Rajikha Raja
  • Function : Author
Adam W Anderson
  • Function : Author
Bennett A Landman

Abstract

White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways, which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography, including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human whole-brain streamlines and asked to segment 14 white matter fascicles on six subjects. In total, we received 57 different bundle segmentation protocols, which enabled detailed volume-based and streamline-based analyses of agreement and disagreement among protocols for each fiber pathway. Results show that even when given the exact same sets of underlying streamlines, the variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection process, including variability within protocols and variability across subjects. In order to foster the use of tractography bundle dissection in routine clinical settings, and as a fundamental analytical tool, future endeavors must aim to resolve and reduce this heterogeneity. Although external validation is needed to verify the anatomical accuracy of bundle dissections, reducing heterogeneity is a step towards reproducible research and may be achieved through the use of standard nomenclature and definitions of white matter bundles and well-chosen constraints and decisions in the dissection process.
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Dates and versions

hal-03346621 , version 1 (16-09-2021)

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Kurt G Schilling, François Rheault, Laurent Petit, Colin B Hansen, Vishwesh Nath, et al.. Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?. NeuroImage, 2021, 243, pp.118502. ⟨10.1016/j.neuroimage.2021.118502⟩. ⟨hal-03346621⟩
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