One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum - Archive ouverte HAL Access content directly
Journal Articles Environment International Year : 2021

One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum

Abstract

The use of freshwater invertebrates for biomonitoring has been increasing for several decades, but little is known about relations between external exposure concentration of metals and their biodistribution among different tissues. One and multi-compartments toxicokinetic (TK) models are powerful tools to formalize and predict how a contaminant is bioaccumulated. The aim of this study is to develop modeling approaches to improve knowledge on dynamic of accumulation and fate of Cd and Hg in gammarid's organs. Gammarids were exposed to dissolved metals (11.1 +/- 1.2 mu g.L-1 of Cd or 0.27 +/- 0.13 mu g.L-1 of Hg) before a depuration phase. At each sampling days, their organs (caeca, cephalon, intestine and remaining tissues) were separated by dissection before analyses. Results allowed us to determine that i) G. fossarum takes up Cd as efficiently as the mussel M. galloprovincialis, but eliminates it more rapidly, ii) organs which accumulate and depurate the most, in terms of concentrations, are caeca and intestine for both metals; iii) the one-compartment TK models is the most relevant for Hg, while the multi-compartments TK model allows a better fit to Cd data, demonstrating dynamic transfer of Cd among organs.
Fichier principal
Vignette du fichier
Gestin (2021).pdf (1.53 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-03343406 , version 1 (17-11-2022)

Identifiers

Cite

Ophélia Gestin, Thomas Lacoue-Labarthe, Marina Coquery, Nicolas Delorme, Laura Garnero, et al.. One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum. Environment International, 2021, 156, pp.106625. ⟨10.1016/j.envint.2021.106625⟩. ⟨hal-03343406⟩
87 View
72 Download

Altmetric

Share

Gmail Facebook X LinkedIn More