Resource availability matters the most in health care system-based outcomes. But health spending is highly unequal across the world and presents varying outcomes. This study aims to investigate the missing part that why some countries failed to have reasonable outcomes despite spending more than those countries that spend less. This study intends to include all those factors that are responsible for improving the costeffectiveness of health expenditures. The study took two data sets, one from the developing countries and second of developed countries as per World Bank classification. As anticipated, there are significant differences in health per capita expenditures. Determinants were also found to behave differently both in the short run and long run as well as across the two data sets.