<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03341439</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T19:34:36+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A receptor-based assay to study bitterness masking effect of yeast extracts</title>
            <author role="aut">
              <persName>
                <forename type="first">Christine</forename>
                <surname>Belloir</surname>
              </persName>
              <email type="md5">40f10b2736e9361f6475adb7618351f1</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">christine-belloir</idno>
              <idno type="idhal" notation="numeric">1207111</idno>
              <idno type="halauthorid" notation="string">597046-1207111</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2991-141X</idno>
              <idno type="IDREF">https://www.idref.fr/079156193</idno>
              <affiliation ref="#struct-1002225"/>
              <affiliation ref="#struct-426438"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Antoine</forename>
                <surname>Thomas</surname>
              </persName>
              <idno type="idhal" notation="numeric">790799</idno>
              <idno type="halauthorid" notation="string">592687-790799</idno>
              <idno type="IDREF">https://www.idref.fr/060742615</idno>
              <affiliation ref="#struct-1086092"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rudy</forename>
                <surname>Menin</surname>
              </persName>
              <idno type="halauthorid">2412421-0</idno>
              <affiliation ref="#struct-1086092"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loïc</forename>
                <surname>Briand</surname>
              </persName>
              <email type="md5">6c5ae23a5cc2652531bf096d08ee1d5f</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">loic-briand</idno>
              <idno type="idhal" notation="numeric">736264</idno>
              <idno type="halauthorid" notation="string">50462-736264</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8175-5936</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?hl=fr&amp;user=Fys527oAAAAJ</idno>
              <idno type="IDPINRA">lbriand</idno>
              <idno type="IDREF">https://www.idref.fr/151710279</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-1002225"/>
              <affiliation ref="#struct-426438"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Sabine</forename>
                <surname>Julien</surname>
              </persName>
              <email type="md5">599961198fd5d3940ea3bf2ff2b93d91</email>
              <email type="domain">inrae.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-09-10 17:46:32</date>
              <date type="whenModified">2025-03-31 08:12:06</date>
              <date type="whenReleased">2021-09-10 17:46:32</date>
              <date type="whenProduced">2021-07-23</date>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="151295">
                <persName>
                  <forename>Sabine</forename>
                  <surname>Julien</surname>
                </persName>
                <email type="md5">599961198fd5d3940ea3bf2ff2b93d91</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03341439</idno>
            <idno type="halUri">https://hal.inrae.fr/hal-03341439</idno>
            <idno type="halBibtex">belloir:hal-03341439</idno>
            <idno type="halRefHtml">2021, Proceedings of the 16. Weurman flavour research symposium, &lt;a target="_blank" href="https://dx.doi.org/10.5281/zenodo.5128287"&gt;&amp;#x27E8;10.5281/zenodo.5128287&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">2021, Proceedings of the 16. Weurman flavour research symposium, &amp;#x27E8;10.5281/zenodo.5128287&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-BOURGOGNE">Université Bourgogne Europe</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CSGA" corresp="UNIV-BOURGOGNE">Centre des Sciences du Goût et de l'Alimentation</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="ALIMH">Département Alimentation Humaine</idno>
            <idno type="stamp" n="INSTITUT-AGRO">Institut Agro</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">Online event (Live and on-demand). Open access conference indexed in OpenAIRE.</note>
            <note type="audience" n="2">International</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A receptor-based assay to study bitterness masking effect of yeast extracts</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Christine</forename>
                    <surname>Belloir</surname>
                  </persName>
                  <email type="md5">40f10b2736e9361f6475adb7618351f1</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">christine-belloir</idno>
                  <idno type="idhal" notation="numeric">1207111</idno>
                  <idno type="halauthorid" notation="string">597046-1207111</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2991-141X</idno>
                  <idno type="IDREF">https://www.idref.fr/079156193</idno>
                  <affiliation ref="#struct-1002225"/>
                  <affiliation ref="#struct-426438"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Antoine</forename>
                    <surname>Thomas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">790799</idno>
                  <idno type="halauthorid" notation="string">592687-790799</idno>
                  <idno type="IDREF">https://www.idref.fr/060742615</idno>
                  <affiliation ref="#struct-1086092"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rudy</forename>
                    <surname>Menin</surname>
                  </persName>
                  <idno type="halauthorid">2412421-0</idno>
                  <affiliation ref="#struct-1086092"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loïc</forename>
                    <surname>Briand</surname>
                  </persName>
                  <email type="md5">6c5ae23a5cc2652531bf096d08ee1d5f</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">loic-briand</idno>
                  <idno type="idhal" notation="numeric">736264</idno>
                  <idno type="halauthorid" notation="string">50462-736264</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8175-5936</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?hl=fr&amp;user=Fys527oAAAAJ</idno>
                  <idno type="IDPINRA">lbriand</idno>
                  <idno type="IDREF">https://www.idref.fr/151710279</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-1002225"/>
                  <affiliation ref="#struct-426438"/>
                </author>
              </analytic>
              <monogr>
                <imprint>
                  <biblScope unit="serie">Proceedings of the 16. Weurman flavour research symposium</biblScope>
                  <date type="datePub">2021-07-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.5281/zenodo.5128287</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">GPCR</term>
                <term xml:lang="en">bitter taste receptor TAS2R</term>
                <term xml:lang="en">inhibition</term>
                <term xml:lang="en">bitter taste</term>
                <term xml:lang="en">yeast extract</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.aen">Life Sciences [q-bio]/Food and Nutrition</classCode>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="vocinrae" n="c_5746">yeast</classCode>
              <classCode scheme="vocinrae" n="c_10156">bitterness</classCode>
              <classCode scheme="vocinrae" n="c_10156">bitter taste</classCode>
              <classCode scheme="vocinrae" n="c_10787">taste</classCode>
              <classCode scheme="vocinrae" n="c_5619">receptor (biochemistry)</classCode>
              <classCode scheme="vocinrae" n="c_383">growth inhibition</classCode>
              <classCode scheme="halTypology" n="PROCEEDINGS">Proceedings</classCode>
              <classCode scheme="halOldTypology" n="DOUV">Directions of work or proceedings</classCode>
              <classCode scheme="halTreeTypology" n="PROCEEDINGS">Proceedings</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Yeast extracts (YEs) are widely used by the food industry for the formulation of foods and beverages, as they bring a natural combination of flavour molecules, including aroma-active and non-volatile compounds (taste-active compounds). Adding a touch of umami, some richness or a typical flavour signature, YEs are used as ingredients to mask the bitterness of some food products. In the present work, using functional calcium mobilization assays, we demonstrated the ability of two different YEs (YE1 and YE2) and the ribonucleotide adenosine 5’ monophosphate (AMP) to stimulate heterologously expressed human bitter taste receptors named TAS2Rs. We then observed that YE1 inhibits the response of two TAS2Rs stimulated by control agonists. Our data demonstrate that the bitterness masking effect of YEs is a molecular mechanism occurring at the receptor level.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1002225" status="OLD">
          <idno type="IdRef">159748593</idno>
          <idno type="RNSR">201019359D</idno>
          <orgName>Centre des Sciences du Goût et de l'Alimentation [Dijon]</orgName>
          <orgName type="acronym">CSGA</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Bourgogne - Bât. CSG - 9E Bd Jeanne d'Arc - 21000 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www2.dijon.inra.fr/csga/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300270" type="direct"/>
            <relation name="UMR6265" active="#struct-415469" type="direct"/>
            <relation name="UMR6265" active="#struct-441569" type="direct"/>
            <relation name="UMR1324" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1086092" status="INCOMING">
          <orgName>Biospringer by Lesaffre</orgName>
          <desc>
            <address>
              <addrLine>94700 Maisons-Alfort</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300270" status="OLD">
          <idno type="IdRef">02819005X</idno>
          <idno type="ISNI">0000000122989313</idno>
          <idno type="ROR">https://ror.org/03k1bsr36</idno>
          <orgName>Université de Bourgogne</orgName>
          <orgName type="acronym">UB</orgName>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bourgogne.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-415469" status="OLD">
          <idno type="IdRef">13996634X</idno>
          <idno type="ROR">https://ror.org/03zek0r74</idno>
          <orgName>AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement</orgName>
          <date type="start">2009-03-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.agrosupdijon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>