Paleoclimate studies in Patagonia show a high Holocene climate variability, strongly controlled by the intensity and latitudinal position of the Southern Westerly Winds. In this study, environmental and climate variability, and in particular winter precipitation, was reconstructed over the last centuries through sedimentological and geochemical analyses of a core from Lake Jeinimeni in North East Patagonia. Visual description, X-ray radiographies and thin section observations point to finely laminated sediments, made by fine sands and light brown clayey silts forming an annual deposition (varves) occasionally interrupted by two Hudson volcano-related tephras and 15 pluri-millimetre to pluri-centimetre coarser sandy to gravely layers. Varve counting confirmed by 210Pb and 137Cs indicates a detrital sequence of at least 750 yr. Based on a correlation with local meteorological data for the 1930–1988AD interval, varve thickness and statistical treatment of XRF geochemical data give information on transport pathway and sedimentary deposit conditions. The sandy laminae correspond to the deposition of high sedimentary load delivered by austral spring snowmelt whereas the clayey silt laminae result of particle settling in the water column during low hydrodynamical conditions. Thicker varves observed in dry conditions underline the importance of aeolian transport in sedimentary deposition. During locally dry and windy summer, the wind may erode and remobilise the sedimentary deposits along the lake margins. The sandy and gravely layers record massive erosional events due to proximal watershed perturbation driven by climatic or tectonic mechanisms. The clastic varves of Lake Jeinimeni document environmental decadal to multidecadal variability in East Patagonia over the last centuries. The more pronounced sediment transition around 1750 CE is consistent with the inception of the Little Ice Age-type event, in agreement with North Patagonian paleoclimate reconstructions derived from glacier advances, lacustrine varve thickness and tree-ring records.