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                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">944-951</biblScope>
                  <date type="datePub">2021-10</date>
                  <date type="dateEpub">2021-07-23</date>
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            <textClass>
              <classCode scheme="mesh">Adult</classCode>
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              <classCode scheme="mesh">Colitis, Ulcerative</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Remission Induction</classCode>
              <classCode scheme="mesh">Treatment Outcome</classCode>
              <classCode scheme="mesh">Ustekinumab</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.heg">Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</classCode>
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              <p>Phase III trials have demonstrated the efficacy and safety of ustekinumab in ulcerative colitis (UC), but few real-life long-term data are currently available. Aims To assess the real-world effectiveness and safety of ustekinumab in patients with UC. Methods From January to September 2019, all consecutive patients with active UC treated with ustekinumab in a GETAID centre were included. Patients were evaluated at week 52. Remission was defined as a partial Mayo Clinic score &amp;lt;= 2. Results We included 103 patients with UC (62 men; mean age: 41.2 +/- 16.2 years; 52% pancolitis E3) with an insufficient response to immunosuppressants, anti-TNFs and/or vedolizumab. At week 52, 45 (44%) patients had discontinued ustekinumab mainly due to lack of effectiveness (n = 41). The cumulative probabilities of ustekinumab persistence were 96.1%, 81.6%, 71.7% and 58.4% after 3, 6, 9 and 12 months respectively. The overall steroid-free clinical remission rate at week 52 was 32% of whom 71% had subscores of null for rectal bleeding and stool frequency. Ten patients underwent colectomy within a median of 6.7 [4.3-10.6] months. Adverse effects were observed in 15 (16.9%) patients; 4 (4.5%) were severe, including one patient who died from a myocardial infarction. Conclusion After 52 weeks, over one-half of patients with refractory UC were still treated by ustekinumab and one-third were in steroid-free clinical remission.</p>
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