The fatty acid composition of cell membranes is critical for the synthesis of lipidic mediators during the inflammatory response and then for the intensity and duration of the inflammation. n-3 polyunsaturated fatty acids (n-3 PUFAs) inhibited the production of pro-inflammatory cytokines and enhanced the production of anti-inflammatory cytokines. The bioactive lipidic mediators synthesized from n-3 PUFAs such as resolvins, maresins, neuroprotectins are responsible for at least some of the anti-inflammatory effects that have been attributed to n-3 PUFAs. Eicosapentaenoic acid has a role in the regulation of mood. Subjects identified as being high on pro-inflammatory markers were more likely to respond to EPA than placebo.