<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03331890</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-26T03:45:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Profiling of N6-methyladenosine dynamics indicates regulation of oyster development by m6A-RNA epitranscriptomes</title>
            <author role="aut">
              <persName>
                <forename type="first">Lorane</forename>
                <surname>Le Franc</surname>
              </persName>
              <email type="md5">3520559fcd66cbfd797428cadab21406</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="numeric">1255487</idno>
              <idno type="halauthorid" notation="string">2035737-1255487</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4051-4415</idno>
              <idno type="IDREF">https://www.idref.fr/255972962</idno>
              <affiliation ref="#struct-542153"/>
              <affiliation ref="#struct-7127"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Petton</surname>
              </persName>
              <email type="md5">462ac1964419a7eca940102ee9d1d5b1</email>
              <email type="domain">ifremer.fr</email>
              <idno type="idhal" notation="string">bruno-petton</idno>
              <idno type="idhal" notation="numeric">182370</idno>
              <idno type="halauthorid" notation="string">20730-182370</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4169-2811</idno>
              <idno type="IDREF">https://www.idref.fr/115018255</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascal</forename>
                <surname>Favrel</surname>
              </persName>
              <email type="md5">af7a3bcb9236c7920acf87a93cc9af46</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="string">pascal-favrel</idno>
              <idno type="idhal" notation="numeric">936933</idno>
              <idno type="halauthorid" notation="string">317598-936933</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2504-9957</idno>
              <affiliation ref="#struct-542153"/>
              <affiliation ref="#struct-7127"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Rivière</surname>
              </persName>
              <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
              <email type="domain">unicaen.fr</email>
              <idno type="idhal" notation="string">guillaume-riviere</idno>
              <idno type="idhal" notation="numeric">179950</idno>
              <idno type="halauthorid" notation="string">5040-179950</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8372-8715</idno>
              <idno type="IDREF">https://www.idref.fr/094812063</idno>
              <affiliation ref="#struct-542153"/>
              <affiliation ref="#struct-7127"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Guillaume</forename>
                <surname>Riviere</surname>
              </persName>
              <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
              <email type="domain">unicaen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-09-02 11:28:21</date>
              <date type="whenModified">2026-05-06 15:37:31</date>
              <date type="whenReleased">2021-09-02 11:28:21</date>
              <date type="whenProduced">2023-08-01</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="748099">
                <persName>
                  <forename>Guillaume</forename>
                  <surname>Riviere</surname>
                </persName>
                <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
                <email type="domain">unicaen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03331890</idno>
            <idno type="halUri">https://hal.science/hal-03331890</idno>
            <idno type="halBibtex">lefranc:hal-03331890</idno>
            <idno type="halRefHtml">&lt;i&gt;Genomics, Proteomics and Bioinformatics&lt;/i&gt;, 2023, pp.742-755. &lt;a target="_blank" href="https://dx.doi.org/10.1101/2021.08.30.458180"&gt;&amp;#x27E8;10.1101/2021.08.30.458180&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Genomics, Proteomics and Bioinformatics, 2023, pp.742-755. &amp;#x27E8;10.1101/2021.08.30.458180&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="MNHN">Muséum National d'Histoire Naturelle</idno>
            <idno type="stamp" n="UNIV-AG">Université des Antilles</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="BOREA" corresp="SORBONNE-UNIVERSITE">Biologie des Organismes Aquatiques et Ecosystèmes</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="TEST5-HALCNRS">collection test 5</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
            <idno type="stamp" n="BOREA-CAEN">Publications des chercheurs caennais de l'UMR BOREA</idno>
            <idno type="stamp" n="SUPRA_SCIENCES_NATURELLES">MNHN</idno>
            <idno type="stamp" n="MERSEA">Marine Ecosystems and oRganisms reSEArch Lab</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Profiling of N6-methyladenosine dynamics indicates regulation of oyster development by m6A-RNA epitranscriptomes</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Lorane</forename>
                    <surname>Le Franc</surname>
                  </persName>
                  <email type="md5">3520559fcd66cbfd797428cadab21406</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="numeric">1255487</idno>
                  <idno type="halauthorid" notation="string">2035737-1255487</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4051-4415</idno>
                  <idno type="IDREF">https://www.idref.fr/255972962</idno>
                  <affiliation ref="#struct-542153"/>
                  <affiliation ref="#struct-7127"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Petton</surname>
                  </persName>
                  <email type="md5">462ac1964419a7eca940102ee9d1d5b1</email>
                  <email type="domain">ifremer.fr</email>
                  <idno type="idhal" notation="string">bruno-petton</idno>
                  <idno type="idhal" notation="numeric">182370</idno>
                  <idno type="halauthorid" notation="string">20730-182370</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4169-2811</idno>
                  <idno type="IDREF">https://www.idref.fr/115018255</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascal</forename>
                    <surname>Favrel</surname>
                  </persName>
                  <email type="md5">af7a3bcb9236c7920acf87a93cc9af46</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="string">pascal-favrel</idno>
                  <idno type="idhal" notation="numeric">936933</idno>
                  <idno type="halauthorid" notation="string">317598-936933</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2504-9957</idno>
                  <affiliation ref="#struct-542153"/>
                  <affiliation ref="#struct-7127"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Rivière</surname>
                  </persName>
                  <email type="md5">0c9bc8ecb528f1aaebdb3acb2abfcadc</email>
                  <email type="domain">unicaen.fr</email>
                  <idno type="idhal" notation="string">guillaume-riviere</idno>
                  <idno type="idhal" notation="numeric">179950</idno>
                  <idno type="halauthorid" notation="string">5040-179950</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8372-8715</idno>
                  <idno type="IDREF">https://www.idref.fr/094812063</idno>
                  <affiliation ref="#struct-542153"/>
                  <affiliation ref="#struct-7127"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13608</idno>
                <idno type="issn">1672-0229</idno>
                <title level="j">Genomics, Proteomics and Bioinformatics</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="pp">742-755</biblScope>
                  <date type="datePub">2023-08-01</date>
                </imprint>
              </monogr>
              <idno type="biorxiv">2021.08.30.458180</idno>
              <idno type="doi">10.1101/2021.08.30.458180</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode>
              <classCode scheme="halDomain" n="sdv.bdd">Life Sciences [q-bio]/Development Biology</classCode>
              <classCode scheme="halDomain" n="sdv.bibs">Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The N6-methylation of RNA adenosines (m6A) is an important regulator of gene expression with critical implications in vertebrate and insect development. However, the developmental significance of epitranscriptomes in lophotrochozoan organisms remains unknown. Using MeRIP-seq, we generated transcriptome-wide m6A-RNA methylomes covering the whole development of the oyster from oocytes to juveniles. Oyster RNA classes display specific m6A signatures, with mRNAs and lncRNAs exhibiting distinct profiles and being highly methylated compared to transposon transcripts. Epitranscriptomes are dynamic and correspond to chronological steps of development (cleavage, gastrulation, organogenesis and metamorphosis), with a minimal mRNA and lncRNA methylation at the morula stage followed by a global increase. mRNA m6A levels are correlated to transcript levels and shifts in methyladenine profiles correspond to expression kinetics. Differentially methylated transcripts cluster according to embryo-larval stages and bear the corresponding developmental functions (cell division, signal transduction, morphogenesis and cell differentiation). The m6A level of transposon transcripts is also regulated and peaks during the gastrulation. We demonstrate that m6A-RNA methylomes are dynamic and associated to gene expression regulation during oyster development. The putative epitranscriptome implication in the cleavage, maternal-to-zygotic transition and cell differentiation in a lophotrochozoan model brings new insights into the control and evolution of developmental processes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-542153" status="OLD">
          <idno type="IdRef">184555752</idno>
          <idno type="ISNI">0000 0004 0370 7482</idno>
          <idno type="RNSR">200919362L</idno>
          <idno type="ROR">https://ror.org/01tp1c480</idno>
          <idno type="Wikidata">Q30262180</idno>
          <orgName>Biologie des Organismes et Ecosystèmes Aquatiques</orgName>
          <orgName type="acronym">BOREA</orgName>
          <date type="start">2014-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Muséum national d'Histoire naturelle - 7, rue Cuvier - CP 32 - 75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://borea.mnhn.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-7512" type="direct"/>
            <relation active="#struct-67872" type="direct"/>
            <relation name="UM95" active="#struct-413221" type="direct"/>
            <relation name="UMR8067 / FRE2030 / UMR7208" active="#struct-441569" type="direct"/>
            <relation active="#struct-524399" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-7512" status="VALID">
          <idno type="IdRef">026394944</idno>
          <idno type="ROR">https://ror.org/03wkt5x30</idno>
          <orgName>Muséum national d'Histoire naturelle</orgName>
          <orgName type="acronym">MNHN</orgName>
          <desc>
            <address>
              <addrLine>57, rue Cuvier - 75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mnhn.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-524399" status="VALID">
          <idno type="IdRef">187841578</idno>
          <idno type="ROR">https://ror.org/02ryfmr77</idno>
          <orgName>Université des Antilles</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-antilles.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>