In the context of building acoustics and the acoustic diagnosis of an existing room, this paper introduces and investigates a new approach to estimate mean absorption coefficients solely from a room impulse response (RIR). This inverse problem is tackled via virtually-supervised learning, namely, the RIR-to-absorption mapping is implicitly learned by regression on a simulated dataset using artificial neural networks. We focus on simple models based on well-understood architectures. The critical choices of geometric, acoustic and simulation pa- rameters used to train the models are extensively discussed and studied, while keeping in mind conditions that are representative of the field of building acoustics. Estimation errors from the learned neural models are compared to those obtained with classical formulas thatrequire knowledge of the room's geometry and reverberation times. Extensive comparisons made on a variety of simulated test sets highlight different conditions under which the learned models can overcome the well-known limitations of the diffuse sound field hypothesis under-lying these formulas. Results obtained on real RIRs measured in an acoustically configurable room show that at 1 kHz and above, the proposed approach performs comparably to classical models when reverberation times can be reliably estimated, and continues to work even when they cannot.