Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nutrients Année : 2021

Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders

Résumé

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for brain functions. They constitute crucial elements of cellular membranes, especially in the brain. They are the precursors of several metabolites with different effects on inflammation and neuron outgrowth. Overall, long-chain PUFAs accumulate in the offspring brain during the embryonic and post-natal periods. In this review, we discuss how they accumulate in the developing brain, considering the maternal dietary supply, the polymorphisms of genes involved in their metabolism, and the differences linked to gender. We also report the mechanisms linking their bioavailability in the developing brain, their transfer from the mother to the embryo through the placenta, and their role in brain development. In addition, data on the potential role of altered bioavailability of long-chain n-3 PUFAs in the etiologies of neurodevelopmental diseases, such as autism, attention deficit and hyperactivity disorder, and schizophrenia, are reviewed.
Fichier principal
Vignette du fichier
NutriNeuro_Nutrients_2021_Martinat.pdf (1.79 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03331131 , version 1 (01-09-2021)
hal-03331131 , version 2 (02-09-2021)

Licence

Paternité

Identifiants

Citer

Maud Martinat, Moira Rossitto, Mathieu Di Miceli, Sophie Layé. Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders. Nutrients, 2021, 13 (4), pp.1185. ⟨10.3390/nu13041185⟩. ⟨hal-03331131v2⟩
36 Consultations
314 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More