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Journal Articles Physical Biology Year : 2020

Fine-tuned regulation of stress priming and thermotolerance

Emmanuel Courtade
  • Function : Author
Quentin Thommen


A common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a usefool tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation protocols for therapeutic purpose.
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hal-03326008 , version 1 (25-08-2021)



Benjamin Pfeuty, Emmanuel Courtade, Quentin Thommen. Fine-tuned regulation of stress priming and thermotolerance. Physical Biology, 2020, ⟨10.1101/2021.01.27.428215⟩. ⟨hal-03326008⟩
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