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Article Dans Une Revue The Breast Année : 2021

Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant

Résumé

Objectives: Comprehensive breast cancer (BC) risk models integrating effects of genetic (GRF) and non- genetic risk factors (NGRF) may refine BC prevention recommendations. We explored the perceived information received on BC risk factors, and related characteristics, in female relatives of women with a BRCA1/2 or PALB2 pathogenic variant, undergoing BC risk assessment using the CanRisk© prediction tool. Methods: Of 200 consecutive cancer-free women approached after the initial genetic consultation, 161 (80.5%) filled in questionnaires on their perception of information received and wished further information on BC risk factors (e.g., being a carrier of a moderate risk altered gene, personal genetic profile, lifestyles). Multilevel multivariate linear models were performed accounting for the clinician who met the counselee and exploring the effect of counselees’ socio-demographic, familial and psychological characteristics on the perceived extent of information received. Results: Perceived no/little information received and wish for further information were more frequent for NGRF (>50%) than for GRF, especially high-risk genes (<20%). Perceived amount of information received and desire for further information were inversely correlated (p=<.0001). Higher education level related to lower perceived levels of information received on GRF. Younger counselees’ age (ß =0.13, p=0.02) and less frequent engagement coping (e.g., inclination to solicit information) (ß =0.24, p=0.02) related to lower perceived information received about NGRF. Other assessed counselees’ features were not found to be associated to GRF and NGRF information perception. Conclusions: Awareness of counselees’ perceived lack of information on BC risk factors indicates a need to enhance evidence-based information on BC NGRF especially.

Domaines

Psychologie Cancer
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Dates et versions

hal-03325413 , version 1 (02-06-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Anne Brédart, Antoine de Pauw, Amélie Anota, Anja Tüchler, Julia Dick, et al.. Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant. The Breast, 2021, 60, pp.38-44. ⟨10.1016/j.breast.2021.08.011⟩. ⟨hal-03325413⟩
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