The impact of epitaxial strain on the structural, electronic, and thermoelectric properties of p-type transparent Sr-doped LaCrO3 thin films has been investigated. For this purpose, high-quality fully strained La0.75Sr0.25CrO3 (LSCO) epitaxial thin films were grown by molecular beam epitaxy on three different (pseudo)cubic (001)-oriented perovskite oxide substrates: LaAlO3, (LaAlO3)0.3(Sr2AlTaO6)0.7, and DyScO3. The lattice mismatch between the LSCO films and the substrates induces in-plane strain ranging from −2.06% (compressive) to +1.75% (tensile). The electric conductivity can be controlled over 2 orders of magnitude, with σ ranging from ∼0.5 S cm–1 (tensile strain) to ∼35 S cm–1 (compressive strain). Consistently, the Seebeck coefficient S can be finely tuned by a factor of almost 2 from ∼127 μV K–1 (compressive strain) to 208 μV K–1 (tensile strain). Interestingly, we show that the thermoelectric power factor (PF = S2σ) can consequently be tuned by almost 2 orders of magnitude. The compressive strain yields a remarkable enhancement by a factor of 3 for 2% compressive strain with respect to almost relaxed films. These results demonstrate that epitaxial strain is a powerful lever to control the electric properties of LSCO and enhance its thermoelectric properties, which is of high interest for various devices and key applications such as thermal energy harvesters, coolers, transparent conductors, photocatalyzers, and spintronic memories.