Expedient synthesis of NOxy-Heterocyclic Carbenes (NOHC) ligands and metal complexes using mechanochemistry - Archive ouverte HAL
Article Dans Une Revue Journal of Organometallic Chemistry Année : 2021

Expedient synthesis of NOxy-Heterocyclic Carbenes (NOHC) ligands and metal complexes using mechanochemistry

Résumé

1,3-Di(benzyloxy)imidazol-2-ylidenes (or NOHCs) possess structures related to N-heterocyclic carbenes (NHCs), with potentially useful applications including the stabilization of metals. In order to prepare NOHC metal complexes, a multi-step synthesis involving mechanochemistry, and making use of ball-milling, was designed. A library of unprecedented NHOC metal complexes were tested for their cytotoxic activities against HCT116 colorectal cancer cell line. The tests demonstrated that the studied complexes displayed a similar activity, comparable with that one exhibited by the ligand. However, a remarkable activity was found in the case of silver complex 5 with an IC50 value of 0.75 μM, comparable to that of doxorubicin.
Fichier principal
Vignette du fichier
Hal-153.pdf (2.13 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03324425 , version 1 (24-08-2021)

Identifiants

Citer

Aneta Wróblewska, Gaëtan Lauriol, Grzegorz Mlostoń, Xavier Bantreil, Frédéric Lamaty. Expedient synthesis of NOxy-Heterocyclic Carbenes (NOHC) ligands and metal complexes using mechanochemistry. Journal of Organometallic Chemistry, 2021, 949, pp.121914. ⟨10.1016/j.jorganchem.2021.121914⟩. ⟨hal-03324425⟩
56 Consultations
66 Téléchargements

Altmetric

Partager

More