Cost-efficient and user-friendly 17O/ 18O labeling procedures of fatty acids using mechanochemistry
Résumé
Two mechanochemical procedures for 17O/18O-isotope labeling of fatty acids are reported: a carboxylic acid activation/hydrolysis approach and a saponification approach. The latter route allowed first-time enrichment of important polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA). Overall, a total of 9 pure labeled products were isolated in high yields (≥80%) and with high enrichment levels (≥37% average labeling of C=O and C-OH carboxylic oxygen atoms), under mild conditions, and in short time (
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https://hal.science/hal-03322217
Soumis le : vendredi 8 octobre 2021-15:33:41
Dernière modification le : mercredi 23 octobre 2024-03:06:30
Archivage à long terme le : dimanche 9 janvier 2022-19:59:42
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- HAL Id : hal-03322217 , version 1
- DOI : 10.1039/D1CC02165F
- PUBMED : 34143162
- PUBMEDCENTRAL : PMC8265319
- WOS : 000663053600001
Citer
Jessica Špačková, Charlyn Fabra, Guillaume Cazals, Marie Hubert-Roux, Isabelle Schmitz-Afonso, et al.. Cost-efficient and user-friendly 17O/ 18O labeling procedures of fatty acids using mechanochemistry. Chemical Communications, 2021, 57 (55), pp.6812-6815. ⟨10.1039/D1CC02165F⟩. ⟨hal-03322217⟩
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