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Article Dans Une Revue Tetrahedron Letters Année : 2021

Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization

Résumé

Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization of O-and N-propargylated compounds is described. The reaction is promoted by potassium tert-butoxide and allows a fast access to interesting heterocycles which were easily converted into 2-arylated pyrroles under acidic conditions.

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Chimie
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Dates et versions

hal-03307256 , version 1 (10-11-2021)

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Ameni Bousbia, Mohamed Lamine Benkhoud, Laurent El Kaim, Sébastien Prévost. Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization. Tetrahedron Letters, 2021, 64, pp.152742. ⟨10.1016/j.tetlet.2020.152742⟩. ⟨hal-03307256⟩
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