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Article Dans Une Revue Non-Coding RNA Année : 2021

Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast

Résumé

Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis.
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hal-03299802 , version 1 (10-11-2021)

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Vedrana Andric, Mathieu Rougemaille. Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast. Non-Coding RNA, 2021, 7 (2), pp.34. ⟨10.3390/ncrna7020034⟩. ⟨hal-03299802⟩
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