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Article Dans Une Revue Journal of Bone and Mineral Research Année : 2004

Paracrine and Autocrine Signals Promoting Full Chondrogenic Differentiation of a Mesoblastic Cell Line

Paracrine and autocrine signals promoting full chondrogenic differentiation of a mesoblastic cell line.

Résumé

The pluripotent mesoblastic C1 cell line was used under serum-free culture conditions to investigate how paracrine and autocrine signals cooperate to drive chondrogenesis. Sequential addition of two systemic hormones, dexamethasone and triiodothyronine, permits full chondrogenic differentiation. The cell intrinsic activation of the BMP signaling pathway and Sox9 expression occurring on mesoblastic condensation is insufficient for recruitment of the progenitors. Dexamethasone-dependent Sox9 upregulation is essential for chondrogenesis.
Differentiation of lineage stem cells relies on cell autonomous regulations modulated by external signals. We used the pluripotent mesoblastic C1 cell line under serum-free culture conditions to investigate how paracrine and autocrine signals cooperate to induce differentiation of a precursor clone along the chondrogenic lineage.

Dates et versions

hal-03297141 , version 1 (23-07-2021)

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Citer

Morgane Locker, Odile Kellermann, Marie Boucquey, Huot Khun, Michel Huerre, et al.. Paracrine and Autocrine Signals Promoting Full Chondrogenic Differentiation of a Mesoblastic Cell Line. Journal of Bone and Mineral Research, 2004, 19 (1), pp.100-110. ⟨10.1359/JBMR.0301206⟩. ⟨hal-03297141⟩

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