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Article Dans Une Revue International Journal of Cancer Année : 2021

Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium

1 IGR - Institut Gustave Roussy
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 Université Paris-Saclay
4 Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
5 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
6 U1018 (Équipe 3) - Épidémiologie des radiations, épidémiologie clinique des cancers et survie
7 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
8 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
9 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
10 SBE - Service de biostatistique et d'épidémiologie
11 CNRGH - Centre National de Recherche en Génomique Humaine
12 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
13 Université Paris Diderot, Sorbonne Paris Cité, Paris, France
14 Institut Jean Godinot [Reims]
15 Registre Général des Tumeurs du Calvados
16 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
17 Hôpital de Taaone
18 Hôpital Louis Pradel [CHU - HCL]
19 HESPER - Health Service and Performance Research
20 Institute of Oncology and Radiobiology
21 OSU - Ohio State University [Columbus]
22 University of Pisa - Università di Pisa
23 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
24 KITZ - Hopp Children's Cancer Center Heidelberg [Heidelber, Germany]
25 DKTK - German Cancer Consortium [Heidelberg]
26 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
27 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
28 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer

Résumé

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid-stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.

Dates et versions

hal-03288145 , version 1 (16-07-2021)

Identifiants

Citer

Thérèse Truong, Fabienne Lesueur, Pierre Emmanuel Sugier, Julie Guibon, Constance Xhaard, et al.. Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium. International Journal of Cancer, 2021, 148 (12), pp.2935-2946. ⟨10.1002/ijc.33488⟩. ⟨hal-03288145⟩
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