The multiscale elasticity model of solids with singular geometrical perturbations of microstructure is considered for the purposes, e.g., of optimum design. The homogenized linear elasticity tensors of first and second orders are considered in the framework of periodic Sobolev spaces. In particular, the sensitivity analysis of second order homogenized elasticity tensor to topological microstructural changes is performed. The derivation of the proposed sensitivities relies on the concept of topological derivative applied within a multiscale constitutive model. The microstructure is topologically perturbed by the nucleation of a small circular inclusion that allows for deriving the sensitivity in its closed form with the help of appropriate adjoint states. The resulting topological derivative is given by a sixth order tensor field over the microstructural domain, which measures how the second order homogenized elasticity tensor changes when a small circular inclusion is introduced at the microscopic level. As a result, the topological derivatives of functionals for multiscale models can be obtained and used in numerical methods of shape and topology optimization of microstructures, including synthesis and optimal design of metamaterials by taking into account the second order mechanical effects. The analysis is performed in two spatial dimensions however the results are valid in three spatial dimensions as well.