Is resistin the master link between inflammation and inflammation-related chronic diseases? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2021

Is resistin the master link between inflammation and inflammation-related chronic diseases?

Résumé

Resistin has been firstly discovered in mice and was identified as an adipose tissue-secreted hormone or adipokine linking obesity and insulin resistance. In humans, resistin has been characterized as a hormone expressed and secreted by Immune cells especially by macrophages, and was linked to many inflammatory responses including inflammation of adipose tissue due to macrophages' infiltration. Human and mouse resistin display sequence and structural similarities and also dissimilarities that could explain their different expression pattern. In mice, strong pieces of evidence clearly associated high resistin plasma levels to obesity and insulin resistance suggesting that resistin could play an important role in the onset and progression of obesity and insulin resistance via resistin-induced inflammation. In humans, the link between resistin and obesity/insulin resistance is still a matter of debate and needs more epidemiological studies. Also, resistin has been linked to other chronic diseases such as cardiovascular diseases and cancers where resistin has been proposed in many studies as a biological marker.
Fichier principal
Vignette du fichier
S0303720721001854.pdf (875.48 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03276128 , version 1 (13-06-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Mohammed Taouis, Yacir Benomar. Is resistin the master link between inflammation and inflammation-related chronic diseases?. Molecular and Cellular Endocrinology, 2021, 533, pp.111341. ⟨10.1016/j.mce.2021.111341⟩. ⟨hal-03276128⟩
38 Consultations
85 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More